Peritoneal carcinomatosis (PC) is a common manifestation of progression in peritoneal and gynecologic malignancies. Current primary strategy in treatment of PC is the concept of regional influence by the way of cytoreductive surgery and intraperitoneal chemotherapy, which has proven the efficiency in treatment of common appendicitis tumors, peritoneum mesothelioma, advanced colorectal cancer, ovarian and gastric cancers. However, in spite of the existing unified criteria for performing cytoreductive surgeries, we observe a lack of a standardized approach for intra-peritoneal chemotherapy, which is used in various variants and regimens in modern clinical practice. Further studies of effectiveness of various intra-peritoneal chemotherapy methods and their combinations are necessary for the development of modern algorithms in treatment of PC.

The information given in the scientific literature sources about the transplantation of autologous adipose tissue (AAT) enriched with stem cells (SC) in cases of breast shape and volume correction (in both aesthetic indications and elimination of postoperative deformities) is characterized by versatile results. This circumstance promotes the purposeful study about the possibilities of modern surgical technologies in use of mesenchymal SC (MSCs) of autologous adipose tissue in cases of mammoplasty. The information on the basic techniques of mesenchymal SC isolation from the AAT has been analyzed. The data of cytological criteria were studied separately that allow to relate this biological substance to the SC. Technical features of stem cells transplantation derived from the autologous adipose transplant in cases of mammoplasty are demonstrated. According to opinion among the competent researchers, elimination of postoperative deformities using cellular technologies is a promising scientific direction of medicine.

Dance movement therapy is a part of art therapy, which implements dance and movement to improve various aspects of a person’s daily functioning, improving his/her physical and emotional state. Dance therapy is especially applicable in older age, when intense stresses are beyond his/her physical capabilities. Elderly people who dance on the regular basis have better flexibility, postural stability, balance, reaction time and cognitive abilities, compared to people of the same age who do not dance. Published evidence support the positive experience of using dance therapy as a method of rehabilitation in elderly patients and subjects with various neurological and mental disorders. Argentine tango represents a promising tool of art therapy, because it is based on biomechanical schemes of movement that are physiological for the human body, includes an improvisation element that stimulates neuroplasticity, and activates social, cognitive, psychological and communicative abilities of the subject. The use of the “educational dance” approach in teaching allows solving several rehabilitation tasks: adaptation of the subject to the process of perception of new information; learning to realize body in motion and build motion on the basis of biofeedback; achievement of maximum comfort during movement and gain a unique manner of movement that is maximally functional for the subject. The acquired skill of conscious movement can become the foundation for further rehabilitation. Thus, argentine tango may be a useful rehabilitation tool for patients with diseases of the nervous system who need to improve motor skills, balance and coordination, and cognitive and communicative capacity. In addition, the use of argentine tango as a motivational factor in comprehensive rehabilitation programs seems promising. The influence of dance therapy on the mood and quality of life in the elderly requires further study in this population.

Actuality. Regional hemodynamics сcontravention is one of the key factors in the development of retinal vein occlusion. The available methods estimating the ocular component of oculoorbital blood flow include opthalmoplethysmography and opthalmorheography. The value of opthalmosphygmography is in question due to the dependence of the results obtained from the orbital component of eye hemodynamics. Assessment of the vascular bed in the fluorescein angiography also gives an indirect assessment of ocular blood flow.

The objective is to estimate hemodynamics indices and informativity of used methods in young and middle-aged patients with retinal vein occlusion.

Materials and methods. The study included 30 patients with retinal vein occlusion. In all patients, routine ophthalmic examination was performed and ocular blood flow was additionally estimated using ophthalmoplethysmography, ophthalmorheography, ophthalmosphygmography, and fluorescein angiography.

Results. Insignificant decrease of ocular blood flow indices was found on the eye with RVO in young and middle-aged patients with retinal vein occlusion. High values of factors weight of opthalmoplethysmography and opthalmorheography was found, which were significantly exceed the contribution of ocular pulse amplitude of pressure.

Conclusions. There was a tendency to decrease all hemodynamic parameters on the eye with RVO in young and middle-aged patients with retinal vein occlusion. The received high values of factors weights reflect the comparable informativity of opthalmoplethysmography and opthalmorheography. The researchers are more informative, which results were less affected by the blood flow in the orbital tissues.

The objective is to assess the economic efficiency of the current practice of complicated IAI (intra-abdominal infections) treatment with antibiotics compared to the strategy of the therapy with carbapenem without antipseudomonal activity (Ertapanem).

Materials and methods. We analyzed the economic efficiency of the current practice of IAI treatment compared to alternative therapy.

Results. In current practice the cost of treatment of 1 case of complicated IAI is 82771.85 rub compared to 91471.55 rub for alternative strategy. Analysis of the impact on the Russian budget, out of the expected number of IAI cases in the Russian Federation, revealed that the current practice of antibacterial therapy allows saving up to 544166014 rubles. The proceeds allows to treat additionally 6574 patients with IAI.

Introduction. External pancreatic fistulas are developed up to 45 % during the postoperative period after the percutaneous drainage of pancreatic pseudocysts. According to some authors this fact is the main contraindication for using of transcutaneous method in  treatment of these patients.

The objective is to optimize the tactics of treatment for minimizing the possible development of external pancreatic fistulas

Materials and methods. Puncture-draining operations were performed in 164 patients with chronic pancreatic pseudocysts. Puncture operations with ultrasound control were primarily performed in 54 patients (32.9 %), they were effective for 29 patients (53.7 %). Traditional surgical interventions were performed in 7 patients (12.9 %) from this group. Percutaneous drainage of pseudocyst was secondary used in 18 patients (33.4 %). Percutaneous drainage of pseudocysts was primarily used in other group consisting of 110 (67.1 %) patients. During the postoperative period, external pancreatic fistula formed in 36 (32.7 %) patients from this group. The fistulas were eliminated by supplementing the transcutaneous interventions with endoscopic methods.

Results. Endoscopic papillosphincterotomy was performed in 36 patients. Pancreatic fistulas were closed after the operation in 12 patients (33.3 %). Endoscopic formation cystogastro-, cystoduodenoanastomosis on «lost drainage» were performed in 9 patients (25 %). Temporary decompression transpapillary stenting of the MPD was performed in 15 patients (41.7 %), endoscopic retrograde stenting was performed in 5 of them. Antegrade stenting of the MPD was transcutaneously performed in 10 patients. There were no lethal outcomes. Fistulas regressed in all patients. Recurrence of cyst formation, pancreatic hypertension were not be to dynamic examinations. Algorithm of treatment was formed and based on the results of a retrospective analysis to treatment of pancreatic cysts in general surgical clinic of «Pavlov First Saint Petersburg State Medical University».

Conclusions. Coherent combining of minimally invasive technologies in the treatment of patients with chronic pancreatic pseudocysts leads to good results: absolute cystic regression and elimination of pancreatic fistulas as appropriate.

Introduction. The relevance of the problem is in high incidence of bladder pain syndrome (BPS) and a significant effect on the quality of life of patients.

The objective of the research is to study the relationship between clinical manifestations and the cystoscopic pattern in women with BPS.

Materials and methods. The results of a survey of 61 women with BPS aged 39 to 68 years are presented. The severity of clinical symptoms was assessed using a PUF questionnaire, a visual analogue pain scale and diaries of urination. All patients underwent cystoscopy after a preliminary hydrodistension of the bladder. Depending on the severity of the clinical manifestations of BPS all patients were divided into 3 groups.

Results. Patients with more severe symptoms of BPS experienced more pronounced changes in the bladder during cystoscopy. Thus, the Gunner lesions were detected only in patients of the 3rd group with the most severe clinical symptoms and in none of the patients of the 1st (mild degree) and the 2 nd group (moderate degree). At the same time, none of the patients of the 3rd group had cystoscopy with normal cystoscopic pattern.

Conclusions. The results of the study showed a correlation between the clinical manifestations of BPS in women and the changes in the bladder detected in cystoscopy after bladder hydrodistension.

Introduction. Nowadays, many evidences about interrelation of inflammatory defeats of parodont and various internal diseases have been collected. Universal molecular and cellular deviations, violations of redox metabolism, pathological activation of apoptosis promote development and progressing of many somatic diseases and the inflammatory diseases of parodont associated with them.

The objective is to evaluate the efficacy of metabolic therapy in patients with coexisting visceral and periodontal diseases.

Materials and methods. 909 patients with visceral diseases associated with generalized periodontitis were examined totally. Group I consisted of 100 patients with chronic infection sites of different localization. Group II consisted of 100 patients with cardiovascular diseasesю Patients from group I and II were divided into two sub-groups, they were prescribed to take metabolic drugs – mexidol (ethylmethylhydroxypyridine succinate) or сycloferon (meglumine acridonacitate) and mildronate (meldonium dehydrate) or cytoflavin (drug succinic acid). Intensity of free radical oxidation in organism was assessed by the products of lipid peroxidation; oxidation of thiol-containing compounds – proteins and low-molecular thiols – was assessed by using direct and back amperometric titration; apoptosis was studied on the model of lymph cells using flow cytometry (Annexin V – FITC); the status of periodontium was assessed with definition of the periodontal index (PI) and community periodontal index of treatment needs (CPITN).

Results. The activity of lipid peroxidation and free radical oxidation of thiols (р<0.01), the level of markers of pathological apoptosis Annexinа V – FITC (р<0.05) were increased in patients with coexisting visceral and periodontal diseases. In the course of the treatment with different metabolic medicines, the activity of lipid peroxidation tended to slow down as identified in both groups of examined patients (p<0.01) and increase thiol-disulfide ratio. In the course of treatment with metabolic drug, the number of cells entering apoptotic phase in patients with visceral and periodontal diseases was significantly fewer (р<0.01).

Introduction. Given the mechanism of the development of halitosis and low efficiency of its self-elimination, means of oral hygiene with antiglycation characteristics should efficiently remove plaque and slow its formation, have antiseptic, antimicrobial and anti-inflammatory properties; have high deodorant quality, strengthen natural defense mechanisms and be safe to oral tissues and organism as a whole. Toothpastes and mouthwashes should consist of components that are able to mask and as well detoxify volatile sulphur and nitrogencontaining compounds produced by microorganisms of the oral cavity. The objective is to evaluate the dynamics of deodorant effect of the means of oral hygiene for identifying the effectiveness of preventive measures among the population.

Materials and methods. At the department of preventive dentistry of the Federal State Budgetary Educational Institution of Higher Education «Pavlov First Saint Petersburg State Medical University” of the Ministry of Healthcare of the Russian Federation, we conducted the diagnostic assessment of halitosis based on the method of index determination of the deodorant effect by Ulitovsky S. B. This method allows to monitor the deodorant effect and in a single definition to determine the level of mouth breathing before using the means of hygiene.

Results. The research revealed that the indicators of index determination of the deodorant effect by Ulitovsky S. B to the end of the study was 44.78±1.73 % in the 1st group and 26.92±1.61 % in the control group. Based on these data, which depended on the degree of antimicrobial activity of personal means of oral hygiene, the examined sample of prophylactic toothpaste showed the significant activity for such test cultures as Ps. aeruginosa, B. cereus and C. albicans.

Conclusions. Based on the evaluating the dynamics of the deodorant effect of the means of oral hygiene throughout the study we identified the increasing of deodorant effect according to the index determination of the deodorant effect by Ulitovsky S. B. By the end of the study, the indicators in the main group were higher than in control group almost in 2 times. With the aim of identifying the most effective means of hygiene for the prevention of halitosis, we evaluated the antimicrobial effect of the prophylactic toothpaste with Cedar essential oil, silver ions, aminoftorid, Savory oil and leaves of the Saro tree. It showed the most pronounced activity against such test cultures as Ps. aeruginosa, B. cereus and C. albicans. The finding indicates high antiglycation effect and deodorant qualities of the examined prophylactic toothpaste.

The work on a comprehensive study of 119 patients with acute inflammatory diseases of maxillo-facial localization (AID MFL) using the method of primary express diagnostics of psycho-sensory-anatomical-functional autodisadaptation (PSAF autodezadaptation) was carried out in “Pavlov First Saint Petersburg State Medical University” and in the Hospital № 15 of St. Petersburg. The analyzed results of the study of 119 patients with AID MFL did not revealed reliable correlation between the severity indicators of the PSAF autodezadaptation, reflecting the patient’s psychological status, and the somatic status, as indicators of the severity of local and systemic inflammatory response syndromes in the body. A systematic approach to the study of patients allowed distinguishing three variants of the course of the disease: balanced, somatopsychic and psychosomatic variant. A psychosomatic variant of the course of AID MFL was observed in 10.4% among the examined patients. Patients with a psychosomatic variant of the course of AID MFL HVL need a psychotherapeutic support from a dental surgeon, a maxillofacial surgeon. High level of autodezadaptation, ineffectiveness of conducted psychotherapeutic measures are the reasons for participation of clinical psychologist or psychotherapist in the treatment of a sick.

Introduction. Mobile phones are worldwide spread nowadays. Smartphones penetration is growing year after year. Numerous studies indicate the negative effect of EMF exposure of these devices on humans. Therefore, it is important to study the peculiarities of their influence on the target organ-the brain. It is important for solving this problem to find out the real situation of the distribution of energy flux density (EFD) of EMF exposure near the front panel of the apparatus.

The aim of the study is to determine and compare EMF exposure from smartphones and classic mobile phones on human head.

Material and methods. The original method patented in the Russian Federation was used in this study. The used original measuring setup is also patented, developed and assembled by the authors of the study. The object of the study was classical mobile phones and smartphones widespread at the time of work.

Results. We got the graphic of matrices of distribution of energy flux density (EFD) of EMF exposure in the plane against the front panel of 10 apparatus corresponding to the topography of a human head. The study revealed peculiarities of this distribution in smartphones and the classic mobile phones and got the values of energy flux density (EFD) of EMF exposure in the investigated devices acting primarily on the brain.

Conclusions. The design of smartphones and mobile phones determines the overall picture of distribution of EFD of EMF exposure in the plane against the front panel for devices of a particular type. This picture must be taken into account when planning epidemiological and experimental studies to obtain comparable results. Progress in the development of mobile communication technologies has led to an increase in the electromagnetic load on users of modern devices.