The article presents some results of an in-depth sociological study of doctors and nurses in the emergency hospital. In the research process the opinion about peculiarities of the organization of work at the ambulance hospital department was studied, Kaliningrad.

The article presents the analysis of the results of sociological studies of the patients admitted to cardiac unit for patients with myocardial infarction and to the Department of medical rehabilitation for such patients. We studied the influence of ethical aspects of conduct of the medical staff, and household conditions in the offices on the level of patients' satisfaction with quality of medical care.

The review contains modern scientific literary data, recently conducted studies, which devoted to studying of molecular, cellular and genetic mechanisms in processes of angiogenesis. The authors describe in detail angiogenesis stages, value of the main proangiogenic and antiangiogenic factors, apoptosis factors, which have different orientation in regulation of blood vessels development. Role of a special population of bone marrow-derived stem cells - endothelial progenitor cells (EPC) in the neovascularization is analyzed. Participation of VEGF-dependent, ANG/Tie-dependent and Notch-signaling pathways, posttranscription regulation of a genome with participation of microRNA in angiogenesis processes are discussed and reviewed.

Genetic factors not only contribute to the development of chronic lymphocytic leukemia (CLL), but also can affect the nature of the pathological process. The study included 30 patients with CLL with indolent and progressive course of the disease. The patients were tested on prevalence of genetic polymorphisms in the genes of the innate immune response. Nineteen polymorphic loci in 14 genes were tested. It was found that with indolent course of CLL, mutant alleles of genes of tumor necrosis factor (TNF) (G-308A), Toll-like receptor (tolllike receptor - TLR) TLR9 (T-1237C) and TLR2 (Arg753Gln) (OR: 4.70, p = 0.05 and OR: 8.33, p = 0.03 and OR: 5.50, p = 0.05, respectively) statistically, were encountered much more frequently . In contrast, combination of normal homozygotes of these genes greatly increased the risk of progressive form of the disease. Presence of TNF gene polymorphism in the polymorphic locus -308, TLR2-753, TLR9-1237 can be associated with the nature of the clinical course of CLL to encourage use these markers as early additional diagnostic and prognostic criteria for unfavorable form of leukemic process in order to optimize chemotherapy.

One of the main causes of local recurrence of rectal cancer is the regional lymphatic nodes metastasis. Existing methods of staging does not have absolute sensitivity and specificity with regard to lesion of regional lymphatic nodes in general, and of lateral group in particular. It is necessary to look for new methods of diagnosis, to identify risk factors and unfavorable prognosis of lateral metastasis in colorectal cancer, which will provide a more differentiated approach to the choice of treatment policy, indications for neoadjuvant chemoradiotherapy and/or lymphatic node dissection. The work on the two groups of patients (control and basic) was performed on the basis of CT performed in angio mode and MRI investigated anatomical variability of middle rectal arteries, proved its impermanence, and studied the relationship between presence of the middle rectal artery and lesion of regional lymphatic nodes in rectal cancer. Prognostic risk factors for lateral metastasis in rectal cancer were proposed, comparative analysis techniques allowing for visualization of the middle rectal vessels was performed.

The purpose of this study was to investigate risk factors for locally-regional recurrence of breast cancer after conservative surgery.

164 patients with moderate to severe ehronie bilateral sensorineural hearing loss were asked to fill in the Glasgow hearing aid benefit profile. Its usefulness was showed in eases of diffieult hearing aid fitting.

Our study was aimed at analysis of expression of genes controlling individual stages of an inflammatory process in combined therapy of chronic obstructive lung disease (COPD). Evaluation of activity of GR, COX-2, and MMP1 genes in blood leukocytes was determined in forty one patients with COPD exacerbations (GOLD stage II to III, Group D) who underwent a two-week combined treatment including Tiotropium Bromide, Formoterol, and glucocotricoid inhalations, as well as parenteral antibacterial treatment. Before and after treatment, relative content of specific mRNAs for GR, GC receptors, and matrix metalloproteinase-1 (COX-2, GR, and MMP1) genes were determined with real-time PCR. Mean values of the gene expression did not significantly differ between the pre- and post-treatment time points. We have found, however, a highly significant correlation between individual changes of the СОХ2, ММР1 и GR gene expression, as well as reverse correlation between СОХ2, GR expression and positive changes in C-reactive protein levels following treatment course. The results of study confirm some interrelations between changes in expression of the inflammation-modulating genes and improvement of clinical parameters after combined drug therapy of the COPD.

The review discusses the role of fibroblast growth factor type 23 (FGF-23) in progression of renal dysfunction and its cardiovascular effects, calcium-phosphorus metabolism in patients with chronic kidney disease. Differences in the FGF-23 effects at predialysis stage of chronic kidney disease, in dialysis patients and renal allograft recipients are analyzed.

Objective. To evaluate the epicardial fat thickness (EFT) in patients with metabolic syndrome (MS), including paroxysmal and persistent atrial fibrillation (AF). To relate EFT to the fibroid heart marker, i.e. galectin 3. Materials and methods. We examined 100 patients with MS (50 with AF), and 50 healthy persons made the control group. Serum galectin 3 was measured by ELISA method. The EFT was measured with echocardiography. Results. EFT in patients with MS was twofold higher than in healthy persons. EFT in patients with MS and AF didn't differ significantly from that in patients with MS without AF. Positive correlation between the levels of EFT and galectin 3 in serum was revealed. Serum galectin 3 and EFT were associated with atrial fibrillation in patients with MS (OR:1,27, 95% CI 1,02-1,58 and OR:1,73, 95% CI 1,37-2,19, correspondingly).Conclusion. Definition of EFT at echocardiography can be used in the assessment of risk AF in patients with MS.

The purpose of this research was the comparing of psychological adaptation characteristics (type of attitude to a disease, psychological defense mechanisms, special aspects of coping-strategy) as exemplified by 2 groups of schizophrenia disorder patients: 1) schizotypal disorders (F-21 according to ICD-10); 2) paranoid schizophrenia (F-20 according to ICD-10). The authors arrived at the conclusion of the same nature if special aspects of psychological adaptation in the groups compared. At the same time, both groups compared showed imbalance of «the level of success» between individual characteristics constituting the module of psychological adaptation. This circumstance testifies to the fact that psychological adaptation in the patients with schizophrenic disorders should be evaluated on a case- bycase basis. In conclusion, the study revealed the necessity to take into consideration of these characteristics during rehabilitation of these patients.

Pecific aspects of cognitive impairments in patients with paranoid schizophrenia depending on the clinical characteristics of the disease have been studied. One hundred and thirty patients were examined. A clinico-psychological, experimental psychological and statistical methods were used. Three main types of cognitive deficiency with paranoid schizophrenia, associated with the onset, disease duration, and severity of psychiatric symptomology : 1) long-term course of the disease accompanied by the average level of clinical symptomology associated with abnormal attention and visuospatial functions; 2) late onset of the disease and unexpressed clinical symptomology combined with memory impairments; 3) acute onset and early age combined with the absence of cognitive impairments.

Tarsal coalition is a pathological condition with abnormal fusion between two or more tarsal bones. The aim of the study was to evaluate effectiveness of conservative treatment in patients with tarsal coalitions. The treatment included reducing the intensity of physical activity, medication, orthotics, physiotherapy. For evaluation of effectiveness of the treatment, we used the AOFAS scale. The results of the study demonstrated that conservative treatment in patients with tarsal coalitions was focused onon temporary pain release. Conservative treatment has limited efficacy for patients with symptomatic tarsal coalitions because of short pain release in the majority of children (98 %). The indications for conservative treatment in patients with symptomatic tarsal coalitions should be pain and hindfoot valgus less than 15°. In other cases, conservative treatment should be considered as preoperative preparation.

Research objective: To assess the impact of AB0 erythrocyte antigens system incompatibility on complications incidence after allogeneic hematopoietic stem cell transplantation (alloHSCT). Patients and methods. The study included 240 patients - recipients for alloHSCT with oncological and hematological diseases. The median age was 19.0 (1-66) years. The research revealed that overall incidence of acute graft-versus-host disease (aGVHD) was higher in the case of AB0-incompatibiIity (p <0.01), and the rate of aGVHD severe forms at AB0-incompatible alloHSCT were observed more often (p = 0.005). At AB0-inco-mpatible unrelative alloHSCT risk of aGVHD was higher (81,3 %) compared to the relative alloHSCT (44 %) (p = 0.002). AB0-incompatibility between donor of HSC and the recipient may be a risk factor for aGVHD.

The paper studied nutritional habits, physical loads, anthropometric and metabolic perfromances, and revealed the changes required to increase the level of adiponectine under drug-free modalities of treatment of patients suffering from abdominal obesity. A 3-year randomized lifestyle intervention trial was performed in 153 patients with AO, age 30-53 yrs, 74 patients (group 1) performed individual hypocaloric diet balanced in fat intake, 79 patients (group 2) performed diet and individual aerobic exercise All patients received individual recommendations on changing their life style. Dynamics of anthropometric, metabolic parameters, physical capacity and adiponectin level were measured. Relation between low level of adiponectin and some metabolic disorders, and sedentary life were revealed. The rate of improving anthropometric parameters, physical capacity, and nutritionassociated with increasing adiponectin was established.

The work is perfromed at the department of the hospital therapy GPMU, laboratory of llergiology and immunology of the research-practical Center of Dental faculty of SpbGMU named after I. Р. Pavlov. State of cellular and humoral immunity at the beginning and at the end of the training year of 15-17 years old young sportsmen of the first level and candidates masters of sports involved in an academic rowing and handball was studied. The athletes of both groups showed significant improvements as compared to the persons not involved in sports, lymphocyte apoptosis inducers (CD95+), the natural killer cells (CD16 + ) and B-lymphocytes (CD20 + ). Over time, in the athletes, regardless the sport, unidirectional changes are detected, encompassing the enhancing of the relative number of CD25+ with receptors for IL2, and immunoglobulin levels.

Currently, in a case if the remission of Graves' disease is not achieved during the long-term antithyroid medication, thyroidectomy should be considered as the treatment of choice. However, the predictive criteria of the surgical treatment outcome are not defined. In this regard, it is important to search criteria contributing to prediction of the results of surgical treatment. According to the findings of the study revealed morphological indicators showing a significantly greater functional activity of the thyroid tissue in patients with postoperative thyrotoxicosis. This requires further study, which may have a significant contribution to the prognosis of postoperative outcomes among patients with Graves' disease.

The article presents the author's self-retrieved data on study of pharmacoepidemiological indicators of consumption of opiates and opioids in St. Petersburg from 2001 to 2013. Pharmaco-epidemiological indicators of consumption of opioids in St. Petersburg and a number of countries are compared. Based on these estimates, the author suggests the ways to optimize provision of patients suffering intense acute and chronic pain with opiates and opioids.

This article reviews epidemiological studies aimed at establishing of association between mobile phone radiation and risk of brain tumors. Only the most relevant and fundamental studies of foreign authors were selected. Both positive and negative results were analyzed to give a straight answer, if mobile phone radiation increases the risk of brain tumors.

The article in question runs about the concept of professional tolerance, how to generate it, and under which conditions.

The article reviewsthe possibility to work out and introduce risk-oriented model for control and surveillance in the field of the sanitary-epidemiological well-being of the population in the Russian Federation. In implementation of risk-oriented approaches, choice of a model is of importance. If the static model is the starting one, then in the future, the dynamic model will be the most promising allowing for assessment of stability of the sanitary-epidemiologic situation in time. Introduction and development of risk-oriented models for control and surveillance is the actual objective at realization of sanitary-epidemiological control (surveillance) . It is necessary to work out and harmonize concept, procedural apparatus, and scientific and methodological support of risk-oriented control and surveillance on the base of the best world patterns and standards.

Study objective: to estimate efficiency of atorvastatin therapy in patients with type 2 diabetes mellitus (T2DM), who are the carrier of various genotypes Q192R paraoxonase gene 1 (PON1). 386 T2DM patients, who have not received statin therapy before, and 187 healthy people were examined. All those examined were exposed to blood lipid profile testing and molecular genetic research. The atorvastatin treatment group included 164 T2DM patients with abnormality of lipids, their blood lipid profile values were assessed before and after 3 months of the therapy. Blood lipid profile values did not differ in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism. Atorvastatin therapy decreased atherogenic lipoprotein levels in type 2 diabetes mellitus patients (T2DM) - the carriers of different Q192R genotypes of paraoxonase gene 1 (PON1) polymorphism, but reduction degree in the carriers of different Q192R genotypes differed - in Q192Q bearers it was greater than in the bearers of Q192R genotype of gene PON1 (р = 0,031). Atorvastatin 3-months therapy revealed greater reduction of total cholesterol in the carriers of Q192Q genotype of gene 1 (PON1) than in the carriers of Q192R genotype of gene 1 (PON1).