Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid. Thirty days old flies treated with nicotinic acid showed better survival rate and reduced neurodegeneration.

The patients (n = 92) who had been operated for homodynamically significant stenoses of the internal carotid artery were under examination. Attention was paid to frequency and clinical features of the post-stroke epilepsy and to specificity of restoration of the AMPA-receptors of glutamate in the post-stroke patients with improving arterial blood flow.

The aim of the research was to study the thymus cellular composition in 45 Vistar rats after experimental hyperthermia (EH). The animals were heated only once to thermoplegia. At different periods of the experiment (5 hours, 3 days after EH) the animals were killed under light narcosis then the thymus was excised for further study. Histologic specimens were prepared according to the basic methods. Immunoblasts, middle-size and small lymphocytes, cells with the mitosis shapes, epithelial cells, and macrophages (1000 magnification) were differentiated in all zones of the thymus on the standard area of 4500 mkm ². Experimental hyperthermia was found to lead to accidental involution of the thymus. Involution of this organ corresponded to the «catabolic» phase of the posthyperthermal period (5 hours, 3 days after EH) that was expressed in the decrease of the relative weight of the organ (25 %), reduction of the relative area of the cortex (15 %) and density of the lymphocytes (12 %). Strengthening of the destructive processes, sings of perivascular oedema and migration of the cellular elements into lymphatic spaces and capillaries were found at the tissue level.

Somatic and psychosomatic risk factors (RF) were studied in 835 patients with arterial hypertension (AH) and ischemic heart disease who had been admitted to the Department of Borderline conditions of MHRI for severity of neurotic and affective disorders provoked by previous psycho-traumatic events (psychosocial stress). Earlier the patients had been under medical supervision of cardiologists or therapeutists at general medicine institutions. Systemic analysis of correlation between somatic, psychic and psycho-social factors responsible for the mechanisms of formation of psychosomatic correlation in the CVD patients with anxiety and depressive disorders in order to estimate the cardiovascular risk and to choose the strategy of the secondary prophylaxis available in the general medicine practice.

Eysenck questionnaire was offered to 45 patients with vascular optical and glaucomaous neuropathy. The results showed that 40 patients (88.9 %) had melancholic temperament. These patients are demonstrated isolation, lability of the nervous system, instability in stressful situations and propensity to development of neuroses.

The aim of our trial was detection of the most significant clinico-laboratory factors in the saliva and blood samples of the patients with odontogenic osteomyelitis in order to predict severity of the clinical course of osteomyelitis and to choose the optimal treatment tactics.

We have studied interrelation between pathological activation of apoptosis and the state and activity of free radical oxidation, and of regional hemodynamics in 27 patients with essential hypertension (EH) and inflammatory periodontal disease. The results show that arterial hypertension is accompanied by tissue hypoxia initiating oxidative modification of proteins and lipids with following pathological activation of apoptosis, that triggers the mechanisms of remodeling of the target organs and results in inflammatory and degenerative forms of periodontal tissue modification as a morphological substrate of remodeling. Therefore periodontium may be looked upon as a target organ of remodeling in EH.

The level of the total, conjugated and unconjugated bilirubin has been assessed after celiac trunk decompression in 621 patients with celiac trunk compression syndrome. Relatively mild, mainly unconjugated hyperbilirubinemia has been found in 23.4 % of the young patients predominantly. The main values of the celiac trunk duplex scanning have been hemodynamically significant. Normalization of bilirubin and its fractions values was seen in most of the patients in the early postoperative course after surgical celiac trunk decompression. The results show the effect of the celiac trunk stenosis and decrease in the liver blood flow on the possible development of unconjugated hyperbilirubinemia in the patients with this artery compression syndrome.

The gallstone disease is a polyetiological pathology. From the literature data we have chosen for our research several risk factors that may lead to development of gallstone disease: diet, smoking, oral combined contraceptives, the number of pregnancies and the ways of fertilization as well as the family history of this disease. We have statistically studied 260 questionnaires filled by the women who had registered their pregnancies (in the period from 8-10 weeks). The results obtained confirmed association between the increased frequency of the gallstone disease because of a great number of pregnancies, or application of assisted reproductive technologies, oral contraceptives and family history but no link with smoking and with the body mass index.

Morphometric parameters and the mineral density of lumbar spine were studied in 929 people (740 women and 189 men) aged 20 - 87 years, living in Karelia. The mineral density of bone was estimated by a method of a two-power x-ray absorptiometriy. The maximum decrease in a mineralization is revealed in the second lumbar vertebra. Decrease in mineral density was accompanied by increase in width of vertebra more at men than at women.

To investigate the state of «the pituitary gland-thyroid gland system» in the patients with undifferentiated dysplasia of the connective tissue (UDCT) 83 young men of the call up age (18.2±0.4 y.o.) were examined. The control group consisted of 26 practically healthy young men of the same age (18.5±0.2 y.o.). Autoimmune thyroiditis (AIT) was diagnosed in 32.5 % of the men with UDCT. The rate of the internal (visceral) phenotypical signs of UDCT in this group was significantly higher than in the men with UDCT but without thyroid problems.

The body weight of 4131 new born boys and girls was studied in four regions of Kirgizstan. The body weight of a newborn was found to be inversely proportional to the altitude of the child residence: the higher was the altitude, the less was the body weight.

Analysis of the anamnestic data, of laboratory parameters and instrumental findings in 189 patients with toxic goiter, who had been operated on because of the lack of the disease remission, showed that during the period from 1970 to 2010, the number of relapses of hyperthyroidism after conservative surgery had increased seven times. The conclusion suggests further search for criteria of prognosing the results of surgical management

The objective of the study was to compare the uterus microflora in healthy women and in the patients with postpartum endometritis using the method of quantitative assessment of contamination of the material. Further examination revealed polymicrobial etiology of the postpartum endometritis. The leading role in the etiological structure belongs to opportunistic microorganisms: enterococci, enterobacteria (preferably Enterococcus faecalis and Proteus mirabilis), and non-spore forming anaerobes (predominantly - Peptostreptococcus spp. аnd Bacteroides spp.), located in the uterus, in most cases, a bulk quantity as aerobically-anaerobic associations.

The article presents the analysis of experience, both of domestic, and of foreign authors in application of the techniques for identification of the blood in the stains on material evidences. The method of definition of IgG by means of ELISA is compared with other modern techniques applied in Russia. Sensitivity, objectivity, actuality and other qualities and advantages of this method are widely displayed when applied in forensic practice.

The axiological potential of the students' work in the Students' Scientific Society (SSS) is deal with in this article. The conditions of the pedagogical process, specificity of the pedagogical guidance, and early involvement of medical students in the work of SSS are described.

The aim of the study was to show the interrelation between the gradually increasing alexithymia traits and the integrative self regulation style of emotional, personal and cognitive interaction with the environment. The Toronto Alexithymia scale was used for examination of 356 students of a medical university. The students were divided into 4 groups in accordance with the alexithymia degree (69 - 94 scores for a high degree). The integral methods of estimation of an individuality were: Temperament Traits Accentuation, Differential estimation of Personal anxiety, Property Concept Discrimination and Copying Strategy. We noticed that the higher was the alexithymia degree the more marked was accentuation of asthenic temperament traits (emotional instability, social and objective passivity) and of personal anxiety (neural-psychic excitability and shyness). There was prevalence of inadaptive copying strategies and abstractive self-controlling style of intellectual activity. Alexithymia is the integral psychological phenomenon combining emotional, volutional, personal and mental parameters of an individuality as a whole. The structure of the phenomenon allows existence of different variants of the components and hence of its typology - the fact of scientific and practical value.

The level of neuropsychic adaptation and regularity of the circadian rhythm of the evacuatory function of the intestine were investigated in the working people. The people were divided - according to the psychic state - into 4 main groups: I - practically healthy people - 22 %, prenosologic condition - 22 %, III - pre-pathologic condition - 27 %, IV - pathology condition - 29 %. The people with the irregular rhythm of the intestine demonstrate worsening of the psychic state from 2 to 6 times more frequently than in the people with a regular rhythm of the intestine.

The aim of the study was to reveal specificity of the anemnesis and of the immune system condition in children with primary peritinitis who had undergone a cavitory operation that failed to reveal the cause of the inflammation and to improve their health. There was some increase of the relative content of activated monocytes with the classic phenotype CD14 ^bright CD16 ^- HLA-DR + versus the total number of monocytes with a phenotype CD14 ^bright.

Comparative assessment of the indices of post-infarction remodelling of the left ventricle was carried out in the patients with myocardium reperfusion (thrombolytic therapy) and without reperfusion. ECG was performed for all patients on admission to the hospital and then 3 and 6 months later. The results obtained demonstrated that after the acute period of myocardial infarction there was no difference between the parameters under control. At the same time the results of dynamic monitoring confirmed that later on the patients felt some peculiarities during the left ventricle remodelling process. Three months later there was an increase of the left ventricle sphericity index during the systoly in the patients of group II. Six months later the patients of group II showed significant difference in five indices of remodelling versus the patients on thrombolitic therapy.

Gastroesophageal reflux disease is a widespread pathology requiring a long-term initial and maintaining therapy. Identification of the risk factors of low compliance of the patient with the treatment of the gastroesophageal reflux disease may be helpful in optimization of the patient - the doctor contact and thus may improve the compliance. The paper describes the predictors of low compliance that may be disclosed in the period of primary contact with the patients with gastroesophagial reflux pathology.