Sputum as a source of adipokines in bronchial asthma
https://doi.org/10.24884/1607-4181-2014-21-3-34-40
Abstract
Forty-four patients with allergic (ABA) and non-allergic (NABA) variants of bronchial asthma (BA) were examined to evaluate levels of key adipokines (leptin, resistin, adiponectin) in sputum in different variants of BA. Adipokines in sputum and blood plasma were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The indices that reflect the percentage of adipokines in sputum regarding adipokines in plasma of the same patients were worked out to evaluate the ratio of levels of corresponding adipokines in plasma and sputum in patients with BA. Two regularities are clearly seen in the study: the first - levels of proinflammatory adipokines (leptin, resistin) in sputum in ABA correlate directly with indicators of respiratory function but levels of anti-inflammatory adipokines (adiponectin) in sputum correlate inversely with indicators of respiratory function; the second -correlation of levels of the studied adipokines with indicators of respiratory function are almost not revealed in NABA. The first regularity reflects the important fact that the content of adipokines in bronchial secretion is to a certain extent one of regulating local mechanisms in target organ controlled system levels of corresponding adipokines in exacerbation of BA.
Keywords
лептин,
резистин,
адипонектин,
мокрота,
бронхиальная астма,
leptin,
resistin,
adiponectin,
sputum,
bronchial asthma
About the Authors
V. N. Mineev
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
T. M. Lalaeva
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
T. S. Vasiljeva
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
A. A. Kuzmina
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
References
1. Жихарев С.С. Основные механизмы защиты бронхолегочной системы // Болезни органов дыхания: рук-во для врачей: в 4 т. Т. 1: Общая пульмонология / Н.И. Александрова, А.Г. Бобков, Н.А. Богданова [и др.]; под. ред. Н.В. Путова. - М.: Медицина, 1989. - С. 112-143.
2. Жихарев С.С. Субклеточные механизмы в регуляции проходимости бронхов // Физиологические и патофизиологические механизмы проходимости бронхов. - Л.: Наука, 1984. - С. 180-210.
3. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Клинико-патогенетическое значение резистина при бронхиальной астме с ожирением // Ученые записки СПбГМУ им. акад. И.П. Павлова. - 2013. - Т. XX. - № 1. - С. 31 - 35.
4. Минеев В.Н., Лалаева Т.М., Трофимов В.И. Бронхиальная астма и ожирение: общие механизмы // Клин. мед. - 2012. - № 4. - С. 4-10.
5. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Кузьмина А.А. Лептин в мокроте у больных бронхиальной астмой // Вестник СПбГУ. Сер. 11. - 2014. - Вып. 3. - С. 50 - 55.
6. Axelsson J., Bergsten A., Qureshi A.R. et al. Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance // Kidney Int. - 2006. - Vol. 69. - P. 596 - 604.
7. Bokarewa M., Nagaev I., Dahlberg L. et al. Resistin, an adipokine with potent proinflammatory properties // J. Immunol. - 2005. - Vol. 174. - P. 5789 - 5795.
8. Fang C., Meng Q., Wu H. et al. Resistin-like molecule-в is a human airway remodelling mediator // Eur. Respir. J. - 2012. - Vol. 39. - P. 458 - 466.
9. Halberg N., SchrawT.D., Wang Z.V. et al. Systemic fate of the adipocyte-derived factor adiponectin // Diabetes. - 2009. - Vol. 58. - P. 1961 - 1970.
10. Holguin F., Rojas M., Brown L., Fitzpatrick A.M. Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls // J. Asthma. - 2011. - Vol. 48. - № 3. - P. 217 - 223.
11. Jensen M.D., Moller N., Nair K. et al. Regional leptin kinetics in humans // Am. J. Clin. Nutr. - 1999. - Vol. 69. - P. 18 - 21.
12. Lessard A., St-Laurent J., Turcotte H., Boule L.-P. Leptin and adiponectin in obese and non-obese subjects with asthma // Biomarkers. - 2011. - Vol. 16. - № 3. - P. 271 - 273.
13. Miller M., Cho J.Y., Pham A. et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease // J. Immunol. - 2009. - Vol. 182. - P. 684 - 691.
14. Miller N.E., Michel C.C., Nanjee M.N. et al. Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport // Am. J. Physiol. Endocrinol. Metab. - 2011. - Vol. 301. - P. E659 - E667.
15. Nair M.G., Du Y., Perrigoue J.G. et al. Alternatively activated macrophage-derived RELM-б is a negative regulator of type 2 inflammation in the lung // J. Exp. Med. - 2009. - Vol. 206. - № 4. - P. 937 - 952.
16. Sideleva O., Suratt B.T., Black K.E. et al. Obesity and Asthma. An inflammatory disease of adipose tissue not the airway // Am. J. Respir. Crit. Care Med. - 2012. - Vol. 186. - № 7. - P. 598 - 605.
17. Sood A., Seagrave J., Herbert G. et al. High sputum total adiponectin is associated with low odds for asthma // J. Asthma. - 2014. - Vol. 51. - № 5. - P. 459 - 460.
18. Sood A., Seagrave J., Herbert G. et al. Asthma is associated with lower adiponectin concentrations in sputum than controls // Am. J. Respir. Crit. Care Med. - 2012. - Vol. 185. - Abstracts. - Р. A6502.
19. Sood A., Shore S.A. Adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies // J. Allergy. - 2013. - Vol. 2013. - Article ID 785835. - 15 pages.
20. Subramanian V., Ferrante A.W. Jr. Obesity, inflammation, and macrophages // Nestle Nutr. Workshop Ser. Pediatr. Program. - 2009. - Vol. 63. - P. 151 - 159.
21. Tacke F., Wustefeld T., Horn R. et al. High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo // J. Hepatol. - 2005. - Vol. 42. - P. 666 - 673.
Review
For citations:
Mineev V.N., Lalaeva T.M., Vasiljeva T.S., Kuzmina A.A. Sputum as a source of adipokines in bronchial asthma. The Scientific Notes of the Pavlov University. 2014;21(3):34-40. (In Russ.) https://doi.org/10.24884/1607-4181-2014-21-3-34-40
Views:
1235
Email this article 