THE EFFECT OF CHRONIC STRESS IN DEVELOPMENT OF THE FIRST SIGNS OF CEREBRAL ATHEROSCLEROSIS BASED ON THE RESEARCH INTO THE INTIMA MEDIA COMPLEX OF CAROTID ARTERY
https://doi.org/10.24884/1607-4181-2017-24-3-48-55
Abstract
Objective. The influence of chronic stress (CS) on increase in thickness of the intima media complex (IMC) of common carotid arteries as a sign of asymptomatic disturbance of the target organs in atherosclerosis was explored.
Materials and methods. 160 railroad engineers (RRE) and 100 healthy volunteers were examined. The activity of the stress systems was measured by the level of stress hormones in the blood (adrenocorticotropic hormone, cortisol, corticosterone). The secretory function of vascular endothelium was measured by release of nitrogen oxide and endothelin-1. The condition of inflammatory activity processes (concentration of high-sensitivity C-reactive protein), total cholesterol and its fractions were studied among the factors affecting the endothelial function. The IMC thickness was measured by duplex scanning. Blood pressure (BP) was measured by Holter monitor.
Results. The effect of CS was accompanied by an increase in stress hormones, development of endothelial dysfunction (ED), progression of inflammatory processes, occurrence of dyslipidemia due to an increase in the content of low-density lipoprotein (LDL), increased BP. Against this background, the IMC thickness increased at a faster rate among RRI.
Conclusions. The effect of the CS factors leads to appearance of ED, which promotes an increase in the thickness of the CMM as a factor of vascular atherosclerosis.
About the Authors
A. A. Skoromec
Federal State Budgetary Educational Institution of Higher Education «Academician I. P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
Конфликт интересов отсутствует
I. S. Lutskyy
M. Gorky Donetsk National Medical University
Ukraine
Competing Interests: Конфликт интересов отсутствует
Ukraine
Igor S. Lutskyy.
Ilicha street, 16, Donetsk, 283003
Competing Interests: Конфликт интересов отсутствует
References
1. Moisan MP , Le Moal M. Overview of acute and chronic stress responses. Med Sci (Paris). 2012 Jun-Jul;28(6-7):612-7.
2. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87:873–904.
3. Гафаров ВВ, Громова ЕА, Гагулин ИВ и др. Изучение влияния стресса на риск артериальной гипертензии в открытой популяции среди мужчин 25-64 лет (эпидемиологическое исследование на основе программы воз «Monica – Psychosocial»). Артериальная гипертензия. 2013;19(1):27-31.
4. Hannerz H, Dalhoff K, Burr H et al. Correlation between relative rates of hospital treatment or death due to ischaemic heart disease (IHD) and of IHD-related medication among sociooccupational and economic activities groups in Denmark, 1996-2005. Int J Occup Med Environ Health. 2014;27(4):536–46.
5. Puzserova A, Slezak P, Balis P et al. Long-term social stress induces nitric oxide-independent endothelial dysfunction in normotensive rats. Stress. 2013 May;16(3):331-9. doi: 10.3109/10253890.2012.725116. Epub 2012 Oct 1.
6. Balkaya M, Prinz V., Custodis F. et al. Stress worsens endothelial function and ischemic stroke via glucocorticoids. Stroke, 2011, 42(11):3258–3264.
7. Jensen HA, Mehta JL. Endothelial cell dysfunction as a novel therapeutic target in atherosclerosis. Expert Rev Cardiovasc Ther.2016 Sep;14(9):1021-33. doi: 10.1080/14779072.2016.1207527. Epub 2016 Jul 14.
8. Lee CJ, Park S. The Role of Carotid Ultrasound for Cardiovascular Risk Stratification beyond Traditional Risk Factors. Yonsei Med J. 2014 May 1;55(3):551-7. doi: 10.3349/ymj.2014.55.3.551. Epub 2014 Apr 1.
9. Kuhlencordt PJ, Gyurko R, Han F et al. Acceleratedatherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation. 2001 Jul 24;104(4):448-54.
10. Ushakov AV, Ivanchenko VS, Gagarina AA. PsychologicalStressin Pathogenesis of EssentialHypertension. Curr Hypertens Rev.2016;12(3):203-214. doi: 10.2174/1573402112666161230121622.
11. Dos Reis DG, Fortaleza EA, Tavares RF et al. Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats. Stress. 2014 Jul;17(4):362-72. doi: 10.3109/10253890.2014.930429.
12. Ong SL, Zhang Y, Sutton M, et al. Hemodynamics of dexamethasone-induced hypertension in the rat. Hypertens Res 2009;32:889–94.
13. Kaprinay B., Bernatova I., Sotnikova R. Effect of Chronic Social Stress on Endothelial Function of the Mesenteric Artery of Normotensive and Spontaneously Hypertensive Rats Vplyv chronického sociálneho stresu na funkciu endotelu mezenterickej artérie normotenzných a spontánne hypertenzných potkanov // Eur. Pharm. J. 2016; Vol. 1.: 23–24. doi: 10.1515/afpuc-2016-0010.
14. Лобзин С.В., Луцкий И.С., Кишеня М.С. Ассоциация полиморфизма гена АСЕ с формированием патологии сердечно-сосудистой системы в условиях действия хронического психо-эмоционального стресса. Вестник Северо-Западного Государственного медицинского университета им. И.И. Мечникова. 2016;3(8):55-61.
15. Molnar GA, Lindschau G, Dubrovska G et al. Glucocorticoid-related signaling effects in vascular smooth muscle cells. Hypertension. 2008;51(5):1372-8.
16. Gavrilovic L., Mandusic V., Stojiljkovic V. et al. Effect of chronic forced running on gene expression of catecholamine biosynthetic enzymes in stellate ganglia of rats. J Biol Regul Homeost Agents. 2012;26(3):367-77.
17. Pardanaud L., Pibouin-Fragner L., Dubrac A. et al. Sympathetic Innervation Promotes Arterial Fate by Enhancing Endothelial ERK Activity. Circ Res. 2016;119(5):607-20. doi: 10.1161/CIRCRESAHA.116.308473.
18. Tao J., Yang Z., Wang J.-M. et al. Effects of Fluid Shear Stress on eNOS mRNA Expression and NO Production in Human Endothelial Progenitor Cells. Cardiology. 2006;106:82–88. doi.org/10.1159/000092636.
19. Xu W,Chen B,Guo L et al. High-sensitivityCRP: possible link between job stress and atherosclerosis.Am J Ind Med. 2015 Jul;58(7):773-9. doi: 10.1002/ajim.22470.
20. Arnaldi G, Scandali VM, Trementino L et al. Pathophysiology of dyslipidemia in Cushing’s syndrome. Neuroendocrinology. 2010;92 Suppl 1:86-90. doi: 10.1159/000314213. Epub 2010 Sep 10.
21. Wu J, Zhang Q, Yang H, Gao X et al. Association between non-high-density-lipoprotein-cholesterol levels and the prevalence of asymptomatic intracranial arterial stenosis / PLoS One. 2013 May 29;8(5):e65229. doi: 10.1371/journal.pone.0065229.
Supplementary files
|
1. ВЛИЯНИЕ ХРОНИЧЕСКОГО СТРЕССА НА ФОРМИРОВАНИЕ РАННИХ ПРИЗНАКОВ ЦЕРЕБРАЛЬНОГО АТЕРОСКЛЕРОЗА ПО РЕЗУЛЬТАТАМ ИЗУЧЕНИЯ КОМПЛЕКСА ИНТИМА-МЕДИА СОННЫХ АРТЕРИЙ | |
| Subject | ||
| Type | Other | |
Download
(40KB)
|
Indexing metadata ▾ | |
|
|
2. ВЛИЯНИЕ ХРОНИЧЕСКОГО СТРЕССА НА ФОРМИРОВАНИЕ РАННИХ ПРИЗНАКОВ ЦЕРЕБРАЛЬНОГО АТЕРОСКЛЕРОЗА ПО РЕЗУЛЬТАТАМ ИЗУЧЕНИЯ КОМПЛЕКСА ИНТИМА-МЕДИА СОННЫХ АРТЕРИЙ | |
| Subject | ||
| Type | Other | |
Download
(49KB)
|
Indexing metadata ▾ | |
|
3. ВЛИЯНИЕ ХРОНИЧЕСКОГО СТРЕССА НА ФОРМИРОВАНИЕ РАННИХ ПРИЗНАКОВ ЦЕРЕБРАЛЬНОГО АТЕРОСКЛЕРОЗА ПО РЕЗУЛЬТАТАМ ИЗУЧЕНИЯ КОМПЛЕКСА ИНТИМА-МЕДИА СОННЫХ АРТЕРИЙ | |
| Subject | ||
| Type | Other | |
Download
(24KB)
|
Indexing metadata ▾ | |
Review
For citations:
Skoromec A.A., Lutskyy I.S. THE EFFECT OF CHRONIC STRESS IN DEVELOPMENT OF THE FIRST SIGNS OF CEREBRAL ATHEROSCLEROSIS BASED ON THE RESEARCH INTO THE INTIMA MEDIA COMPLEX OF CAROTID ARTERY. The Scientific Notes of the Pavlov University. 2017;24(3):48-55. (In Russ.) https://doi.org/10.24884/1607-4181-2017-24-3-48-55
Views:
1058
Email this article 