Distribution of genotypes and alleles of the aldosterone-synthase gene in patients with abdominal obesity

We observed 140 patients with abdominal obesity (AO) (IDF, 2005), the residents of St. Petersburg (44.6 ± 0.6 years). Metabolic syndrome (MS) (IDF, 2005) was diagnosed in 49.2% of patients with AO. The most frequent component of MS in patients with AO was arterial hypertension (AH). The distribution of genotypes and -alleles of the aldosterone-synthase gene in patients with AO and in the comparison group (56 subjects without AO, 41.0 ± 1.1 years) didn't differ (p> 0.05). Levels of both systolic and diastolic blood pressure (BP) were higher in carriers of -344T allele of aldosterone-synthase gene. Plasma renin activity, plasma aldosterone and glucose levels, anthropometric parameters, serum blood lipids and carbohydrate metabolism indices in obese patients with different genotypes of aldosterone-synthase gene didn't differ. -344T allele of aldosterone-synthase gene in patients with AO is associated with the increased risk of AH.

абдоминальное ожирение, артериальная гипертензия, ренин-ангиотензин-альдостероновая система, полиморфизм, альдостерон-синтаза, Abdominal obesity, arterial hypertension, renin-angiotensin-aldosterone system, polymorphism, aldosterone-synthase

1. Баженова Е. А., Беляева О. Д., Березина А. В. и др. Ренин-ангиотензин-альдостероновая система у больных абдоминальным ожирением и артериальной гипертензией // Артериальная. гипертензия. - 2013. - Т. 19. - № 5. - С. 389-396.

2. Благосклонная Я. В., Шляхто Е. В., Бабенко А. Ю. Эндокринология: учеб. для мед. вузов. - СПб.: СпецЛит, 2004. - 398 с.

3. Alvarez-Madrazo S. L., Mackenzie S. M., Davies E. et al. Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence Юг a digenic influence on hypertension // Hypertension. - 2013. - Vol. 61 (1). - Р. 232 - 239.

4. Barbato A., Russo P., Siani A. et al. Aldosterone synthase gene (CYP11B2) C-344T polymorphism, plasma aldosterone, renin activity and blood pressure in a multi-ethnic population // J. Hypertens. - 2004. - Vol. 22 (10). - Р. 1895-1901.

5. Batra A., Siegmund B. Role of visceral fat. // Dig. Dis. - 2012. - Vol. 30. - № 1. - Р. 70 - 74.

6. Belline N. M., Foucn L., Fumeron F. et al. Association of the -344 T>C and the 3097 G>A polymorphisms of CYP11B2 gene with hypertension, type 2 diabetes, and metabolic syndrome in French population // Am. J. Hypert. - 2010. - Vol. 23 (6). - P. 660 - 667.

7. Cassis L. A., Police S. B., Yiannikouris F., Thatcher S. E. Local Adipose Tissue Renin-Angiotensin System // Cun'. Hypertens. - 2008. - Vol. 10. - № 2. - Р. 93 - 98.

8. Fuentes E., Fuentes F., Vilahur G. et al. Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome // Mediator Inflamm. - 2013. - Vol. 2013. - Р. 11.

9. Gu D., Ge D., He J. et al. Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated of stage-2 hypertension in northern Han Chinese // Clin. Genet. - 2004. - Vol. 66 (5). - P. 409 - 416.

10. Hlubocka Z., Jachymova M., Heller S. et al. Association of the -344T/C aldosterone synthase gene variant with essential hypertension // Physiol Res. - 2009. - Vol. 58 (6). - Р. 785 - 792.

11. Ji L., Cai X., Zhang L. et al. Association between polymorphism in the renin-angiotensin-aldosterone system genes and essential hypertension in the Han Chinese Population // Plos. one. - 2013. - Vol. 28. - № 8 (8). - Р. e72701.

12. Kim H. K., Lee H., Kwon J. T., Kim H. J. A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure // J. Renin Angiotensin Aldosterone Syst. - 2014. - № 16. - pii: 1470320313516174. [Epub ahead of print]

13. Kim Y. R., Kim S. H., Kang S. H. et al. Association of CYP11B2 polymorphisms with metabolic syndrome patients // Biomed. Rep. - 2014. - Vol. 2 (5). - Р. 749 - 754.

14. Li Y., Yang P., Wu S. L. et al. Effect of CYP11B2 gene -344T/C polymorphism on renin-angiotensin-aldosterone system activity and blood pressure response to hydrochlorothiazide // Zhonghua Yi Xue Yi Chuan Xue Za Zhi. - 2012. - Vol. 29 (1). - Р. 68 - 71.

15. Matthews D., Hosker J., Rudeski D. et al. Homeostasis model assesment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentration in men // Diabetologia. - 1995. - Vol. 28. - № 7. - P. 412 - 419.

16. Munshi A., Sharma V., Kaul S. et al. Association of the -344C/T aldosterone synthase (CYP11B2) gene variant with hypertension and stroke // J. Neurol. Sci. - 2010. - Vol. 296 (1 - 2). - Р. 34 - 38.

17. Pacholczyk M., Ferenc T., Kowalski J. et al. Association of angiotensin-converting enzyme and angiotensin II type I receptor gene polymorphisms with extreme obesity in Polish individuals // DNA Cell. Biol. - 2013. - Vol. 32 (8). - Р. 435 - 444.

18. Payne J. R., Dhamrait S. S., Toorl. S. et al. The -344T>C promoter variant of the gene for aldosterone synthase (CYP11B2) is not associated with cardiovascular risk in a prospective study of UK healthy men // Atherosclerosis. - 2004. - Vol. 174 (1). -Р. 81 - 86.

19. Russo P., Lauria F., Loguercio M. et al. -344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men // Am. J. Hypert. - 2007. - Vol. 20 (2). - P. 218 - 222.

20. Saidi S., Mahjoub T., Almawi W. Y. Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs // J. Renin Angiotensin Aldosterone Syst. - 2010. - Vol. 11 (3). - Р. 180-186.

21. Scharma A. M. The Obese Patient with Diabetes Mellitus: from Research Targets to Treatment Options // Am. J. Med. - 2006. - Vol. 119. - № 5 (Suppl. 1). - Р. S17 - S23.

22. Shields M., Tremblay V. S., Janssen I. Abdominal Obesity and Cardiovascular disease Risk Factors within Body Mass Index Categories // Health Reports. - 2012. - Vol. 23. - № 2. - Р. 7-15.

23. Sookoian S., Gianotti T. F., Gonzales C. D. et al. Association of the C-344T aldosterone synthase gene variant with essential hypertension: a meta-analysis // J. Hypert. - 2007. - Vol. 25 (1). - P. 5-13.

24. Tiago A. D., Badenhorst D., Nkeh B. et al. Impact of renin-angiotensin-aldosterone system gene variants on the severity of hypertension in patients with newly diagnosed hypertension // Am. J. Hypertens. - 2003. - Vol. 16 (12). - Р. 1006-1010.