THE POSSIBILITIES OF MAMMOPLASTY USING THE TRANSPLANTATION OF AUTOLOGOUS ADIPOSE TISSUE ENRICHED WITH STEM CELLS
https://doi.org/10.24884/1607-4181-2017-24-4-13-20
Abstract
The information given in the scientific literature sources about the transplantation of autologous adipose tissue (AAT) enriched with stem cells (SC) in cases of breast shape and volume correction (in both aesthetic indications and elimination of postoperative deformities) is characterized by versatile results. This circumstance promotes the purposeful study about the possibilities of modern surgical technologies in use of mesenchymal SC (MSCs) of autologous adipose tissue in cases of mammoplasty. The information on the basic techniques of mesenchymal SC isolation from the AAT has been analyzed. The data of cytological criteria were studied separately that allow to relate this biological substance to the SC. Technical features of stem cells transplantation derived from the autologous adipose transplant in cases of mammoplasty are demonstrated. According to opinion among the competent researchers, elimination of postoperative deformities using cellular technologies is a promising scientific direction of medicine.
About the Authors
N. S. RomanenkovRussian Federation
Nikolay S. Romanenkov.
Shkapina street, 30, Saint-Petersburg, 198095
K. N. Movchan
Russian Federation
References
1. Ginsburg O, Bray F, Coleman MP, Vanderpuye V, Eniu A, Kotha SR, Sarker M, Huong TT, Allemani C, Dvaladze A, Gralow J, Yeates K, Taylor C, Oomman N, Krishnan S, Sullivan R, Kombe D, Blas MM, Parham G, Kassami N, Conteh L. The global burden of women’s cancers: a grand challenge in global health. Lancet. 2017;389(10071):847-860. https://doi.org/10.1016/s0140-6736(16)31392-7
2. Icaza G., Núñez L., Bugueño H. Epidemiological analysis of breast cancer mortality in women in Chile. Rev Med Chil. 2017;145(1):106-114. https://doi.org/10.4067/s0034-98872017000100014
3. Khizha ValVas, Movchan KN, Popov SV, Skryabin ON, Grinеnko OA, Rusakevich KI, Khizha VitVal. The statistical datа of cancer cases in Saint Petersburg within 2011–2015. Vestnik SPbSU. Medicine. 2017;12(1):60–81. https://doi.org/10.21638/11701/spbu11.2017.106 (In Russ.)
4. Lee J.W., Kim M.C., Park H.Y., Yang J.D. Oncoplastic volume replacement techniques according to the excised volume and tumor location in small- to moderate-sized breasts. Gland Surg. 2014;3(1):14-21. https://doi.org/10.3978/j.issn.2227-684X.2014.02.02
5. Neuber G. Fettransplantation. Verhandlungen der deutschen Gesellschaft für Chirurgie. Zentralbl. Chir. 1893; 22: 66.
6. Lexer E. Freie Fetttransplantation. Deutsch Med. Wochenschr. 1910;36:640
7. Brayfield C, Marra K, Rubin JP. Adipose stem cells for soft tissue regeneration. Handchir. Mikrochir. Plast. Chir. 2010; 42(2):124-8. https://doi.org/10.1055/s-0030-1248269
8. Ebrahimian TG, Pouzoulet F, Squiban C, Buard V, André M, Cousin B, Gourmelon P, Benderitter M, Casteilla L, Tamarat R. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler. Thromb. Vasc. Biol. 2009;29(4):503-10. https://doi.org/10.1161/atvbaha.108.178962
9. Koh KS, Oh TS, Kim H, Chung IW, Lee KW, Lee HB, Park EJ, Jung JS, Shin IS, Ra JC, Choi JW. Clinical application of human adipose tissue-derived mesenchymal stem cells in progressive hemifacial atrophy (Parry-Romberg disease) with microfat grafting techniques using 3-dimensional computed tomography and 3-dimensional camera. Ann. Plast. Surg. 2012;69(3):331-7. https://doi.org/10.1097/sap.0b013e31826239f0
10. Rigotti G, Marchi A, Galiè M, Baroni G, Benati D, Krampera M, Pasini A, Sbarbati A. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119(5):1409-22; discussion 1423-4. https://doi.org/10.1097/01.prs.0000256047.47909.71
11. Brown SA, Levi B, Lequeux C, Wong VW, Mojallal A, Longaker MT. Basic science review on adipose tissue for clinicians. Plast. Reconstr. Surg. 2010;126(6):1936-46. https://doi.org/10.1097/PRS.0b013e3181f44790
12. Matsumoto D, Sato K, Gonda K, Takaki Y, Shigeura T, Sato T, Aiba-Kojima E, Iizuka F, Inoue K, Suga H, Yoshimura K. Cell-assisted lipotransfer: supportive use of human adiposederived cells for soft tissue augmentation with lipoinjection Tissue Eng. 2006 Dec; 12(12):3375-82. https://doi.org/10.1089/ten.2006.12.3375
13. Buschmann J, Gao S, Härter L, Hemmi S, Welti M, Werner CM, Calcagni M, Cinelli P, Wanner GA. Yield and proliferation rate of adipose-derived stromal cells as a function of age, body mass index and harvest site-increasing the yield by use of adherent and supernatant fractions? Cytotherapy. 2013; 15(9):1098-105. https://doi.org/10.1016/j.jcyt.2013.04.009
14. Francis MP, Sachs PC, Elmore LW, Holt SE. Isolating adipose-derived mesenchymal stem cells from lipoaspirate, blood and saline fraction. Organogenesis. 2010;6(1):11-4. https://doi.org/10.4161/org.6.1.10019
15. Gnanasegaran N, Govindasamy V, Musa S, Kasim NH. Different isolation methods alter the gene expression profiling of adipose derived stem cells. Int. J. Med. Sci. 2014;11(4):391-403. https://doi.org/10.7150/ijms.7697
16. Torio-Padron N, Huotari AM, Eisenhardt SU, Borges J, Stark GB. Comparison of Pre-Adipocyte Yield, Growth and Differentiation Characteristics from Excised versus Aspirated Adipose Tissue. Cells Tissues Organs. 2010;191(5):365-71. https://doi.org/10.1159/000276594
17. Oedayrajsingh-Varma MJ, van Ham SM, Knippenberg M, Helder MN, Klein-Nulend J, Schouten TE, Ritt MJ, van Milligen FJ. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissueharvesting procedure Cytotherapy. 2006;8(2):166-77. https://doi.org/10.1080/14653240600621125
18. Schreml S, Babilas P, Fruth S, Orsó E, Schmitz G, Mueller MB, Nerlich M, Prantl L. Harvesting human adipose tissue-derived adult stem cells: resection versus liposuction. Cytotherapy. 2009;11(7):947-57. https://doi.org/10.3109/14653240903204322
19. Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, March KL, Redl H, Rubin JP, Yoshimura K, Gimble JM. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013;15(6):641-8. https://doi.org/10.1016/j.jcyt.2013.02.006
20. Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E, Sato K, Inoue K, Nagase T, Koshima I, Gonda K. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J. Cell Physiol. 2006;208(1):64-76. https://doi.org/10.1002/jcp.20636
21. Zeng G, Lai K, Li J, Zou Y, Huang H, Liang J, Tang X, Wei J, Zhang P. A rapid and efficient method for primary culture of human adipose-derived stem cells. Organogenesis. 2013;9(4):287-95. https://doi.org/10.4161/org.27153
22. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-7. https://doi.org/10.1080/14653240600855905
23. Sensebe L, Bourin P, Tarte K. Good manufacturing practices production of mesenchymal stem/stromal cells. Hum. Gene. Ther. 2011; 22(1): 19-26. https://doi.org/10.1089/hum.2010.197
24. Gimble JM, Guilak F, Bunnell BA. Clinical and preclinical translation of cell-based therapies using adipose tissuederived cells. Stem Cell Res. Ther. 2010;1(2):19. https://doi.org/10.1186/scrt19
25. Higuchi A, Chuang CW, Ling QD, Huang SC, Ling MW, Chen H, Chang Y, Wang HC, Bing JT, Chang Y, Hsu ST Differentiation ability of adipose-derived stem cells separated from adipose tissue by a membrane filtration method. J. Membr. Sci. 2011;366(2):286-94. https://doi.org/10.1016/j.memsci.2010.10.009
26. Strem BM, Hicok KC, Zhu M, Wulur I, Alfonso Z, Schreiber RE, Fraser JK, Hedrick MH. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med. 2005;54(3):132-41. https://doi.org/10.2302/kjm.54.132
27. Thesleff T, Lehtimäki K, Niskakangas T, Mannerström B, Miettinen S, Suuronen R, Öhman J. Cranioplasty with adiposederived stem cells and biomaterial: a novel method for cranial reconstruction. Neurosurgery. 2011;68(6):1535-40. https://doi.org/10.1227/neu.0b013e31820ee24e
28. Kolle SF, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomized placebo-controlled trial. Lancet. 2013;382(9898):1113-20. https://doi.org/10.1016/s0140-6736(13)61410-5
29. Pinheiro CH, de Queiroz JC, Guimarães-Ferreira L, Vitzel KF, Nachbar RT, de Sousa LG, de Souza-Jr AL, Nunes MT, Curi R. Local injections of adipose-derived mesenchymal stem cells modulate inflammation and increase angiogenesis ameliorating the dystrophic phenotype in dystrophin-deficient skeletal muscle. Stem Cell Rev. 2012;8(2):363-74. https://doi.org/10.1007/s12015-011-9304-0
30. Tiryaki T, Findikli N, Tiryaki D. Staged stem cellenriched tissue (SET) injections for soft tissue augmentation in hostile recipient areas: a preliminary report. Aesthetic Plast. Surg. 2011;35(6):965-71. https://doi.org/10.1007/s00266-011-9716-x
31. Salgado AJ, Reis RL, Sousa NJ, Gimble JM. Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine. Curr. Stem Cell Res. Ther. 2010;5(2):103-10. https://doi.org/10.2174/157488810791268564
32. Sheng L, Yang M, Li H, Du Z, Yang Y, Li Q. Transplantation of adipose stromal cells promotes neovascularization of random skin flaps. Tohoku J. Exp. Med. 2011;224(3):229-34. https://doi.org/10.1620/tjem.224.229
33. Kasem A, Wazir U, Headon H, Mokbel K. Breast Lipofilling: A Review of Current Practice. Arch Plast Surg. 2015 Mar;42(2):126-30. ttps://doi.org/10.5999/aps.2015.42.2.126
34. Zheng DN, Li QF, Lei H, Zheng SW, Xie YZ, Xu QH, Yun X, Pu LL. Autologous fat grafting to the breast for cosmetic enhancement: experience in 66 patients with long-term follow up. J. Plast. Reconstr. Aesthet. Surg. 2008;61(7):792-8. https://doi.org/10.1016/j.bjps.2007.08.036
35. Coleman S.R., Saboeiro A.P. Fat grafting to the breast revisited: safety and efficacy. Plast. Reconstr. Surg. 2007;119(3):775-85; discussion 786-7. https://doi.org/10.1097/01.prs.0000252001.59162.c9
36. Kamakura T, Ito K. Autologous cell-enriched fat grafting for breast augmentation. Aesthetic Plast Surg. 2011;35(6):1022-30. https://doi.org/10.1007/s00266-011-9727-7
37. Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, Harii K. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg. 2008 Jan;32(1):48-55; discussion 56-7. https://doi.org/10.1007/s00266-007-9019-4
38. Peltoniemi HH, Salmi A, Miettinen S, Mannerström B, Saariniemi K, Mikkonen R, Kuokkanen H, Herold C. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: A prospective comparative study. J. Plast. Reconstr. Aesthet. Surg. 2013;66(11):1494-503. https://doi.org/10.1016/j.bjps.2013.06.002
39. Zhu M, Zhou Z, Chen Y, Schreiber R, Ransom JT, Fraser JK, Hedrick MH, Pinkernell K, Kuo HC. Supplementation of fat grafts with adipose-derived regenerative cells improves long-term graft retention. Ann Plast Surg. 2010 Feb;64(2):222-8. https://doi.org/10.1097/sap.0b013e31819ae05c
40. Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449(7162):557-63. https://doi.org/10.1038/nature06188
41. Rowan BG, Gimble JM, Sheng M, Anbalagan M, Jones RK, Frazier TP, Asher M, Lacayo EA, Friedlander PL, Kutner R, Chiu ES. Human adipose tissue-derived stromal/stem cells promote migration and early metastasis of triple negative breast cancer xenografts. PLoS One. 2014;9(2):e89595. https://doi.org/10.1371/journal.pone.0089595
42. Eterno V, Zambelli A, Pavesi L, Villani L, Zanini V, Petrolo G, Manera S, Tuscano A, Amato A. Adipose-derived Mesenchymal Stem Cells (ASCs) may favour breast cancer recurrenceviaHGF/c-Met signaling. Oncotarget. 2014;5(3):613-33. https://doi.org/10.18632/oncotarget.1359
43. Zimmerlin L, Donnenberg AD, Rubin JP, Basse P, Landreneau RJ, Donnenberg VS. Regenerative therapy and cancer: in vitro and in vivo studies of the interaction between adipose-derived stem cells and breast cancer cells from clinical isolates. Tissue Eng. Part A. 2011;17(1-2):93-106. https://doi.org/10.1089/ten.tea.2010.0248
44. Pérez-Cano R, Vranckx JJ, Lasso JM, Calabrese C, Merck B, Milstein AM, Sassoon E, Delay E, Weiler-Mithoff EM. Prospective trial of Adipose-Derived Regenerative Cell (ADRC)-enriched fatgrafting for partial mastectomy defects: The RESTORE-2 trial.Eur. J. Surg. Oncol. 2012;38(5):382-9. https://doi.org/10.1016/j.ejso.2012.02.178
45. Hamza A, Lohsiriwat V, Rietjens M. Lipofilling in breast cancer surgery. Gland Surg. 2013;2(1):7-14. https://doi.org/10.3978/j.issn.2227-684X.2013.02.03
46. Lampert F.M., Grabin S., Bjorn Stark G. The RESTORE-2 trial: proof of safety and efficacy of «regenerative-cell enriched»; fat-grafting? Eur. J. Surg. Oncol. 2012;38(12):1231-2; author reply 1233-4. https://doi.org/10.1016/j.ejso.2012.08.014
47. Zhou Y, Wang J, Li H, Liang X, Bae J, Huang X, Li Q. Efficacy and Safety of Cell-Assisted Lipotransfer: A Systematic Review and Meta-Analysis. Plast Reconstr. Surg. 2016;137(1):44e57e. https://doi.org/10.1097/prs.0000000000001981
Review
For citations:
Romanenkov N.S., Movchan K.N. THE POSSIBILITIES OF MAMMOPLASTY USING THE TRANSPLANTATION OF AUTOLOGOUS ADIPOSE TISSUE ENRICHED WITH STEM CELLS. The Scientific Notes of the Pavlov University. 2017;24(4):13-20. (In Russ.) https://doi.org/10.24884/1607-4181-2017-24-4-13-20