EYE HEMODYNAMICS IN YOUNG AND MIDDLE-AGED PATIENTS WITH RETINAL VEIN OCCLUSION

Actuality. Regional hemodynamics сcontravention is one of the key factors in the development of retinal vein occlusion. The available methods estimating the ocular component of oculoorbital blood flow include opthalmoplethysmography and opthalmorheography. The value of opthalmosphygmography is in question due to the dependence of the results obtained from the orbital component of eye hemodynamics. Assessment of the vascular bed in the fluorescein angiography also gives an indirect assessment of ocular blood flow.

The objective is to estimate hemodynamics indices and informativity of used methods in young and middle-aged patients with retinal vein occlusion.

Materials and methods. The study included 30 patients with retinal vein occlusion. In all patients, routine ophthalmic examination was performed and ocular blood flow was additionally estimated using ophthalmoplethysmography, ophthalmorheography, ophthalmosphygmography, and fluorescein angiography.

Results. Insignificant decrease of ocular blood flow indices was found on the eye with RVO in young and middle-aged patients with retinal vein occlusion. High values of factors weight of opthalmoplethysmography and opthalmorheography was found, which were significantly exceed the contribution of ocular pulse amplitude of pressure.

Conclusions. There was a tendency to decrease all hemodynamic parameters on the eye with RVO in young and middle-aged patients with retinal vein occlusion. The received high values of factors weights reflect the comparable informativity of opthalmoplethysmography and opthalmorheography. The researchers are more informative, which results were less affected by the blood flow in the orbital tissues.

1. Geyer O., Neudorfer M., Snir T. et al. Pulsatile ocular blood flow in diabetic retinopathy. Acta. Ophthalmol. Scand. 1999;77(5):522–525.

2. Abegão Pinto L., Willekens K., Van Keer K. et al. Ocular blood flow in glaucoma – the Leuven Eye Study. Acta Ophthalmol. 2016;94(6):592-598.

3. Tultseva S.N., Titarenko A.I., Rukhovets A.G. Characteristics of systemic and regional hemodynamics in ischemic retinal vein occlusion in young and middle-aged adults. Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2016;2(58):24-31. [In Russian]

4. Tultseva S.N. Anatomical and hemodynamic prerequisites for retinal vein occlusion development. Oftalmolog. Vedomosti. 2011;IV(4):70–76. [In Russian]

5. Astakhov Y.S., Tultseva S.N., Titarenko A.I. The role of endothelium dysfunction in the pathogenesis of vascular ocular diseases. Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2017;4(60):5-16. [In Russian].

6. Astakhov Y.S., Dzhaliashvili O.A. The contemporary tendency in the eye hemodynamics research in glaucoma. Oftal’molog. zhurn. 1990;3:179–183. [In Russian]

7. Rukhovets A.G., Astakhov Y.S. Methods of pulsatile ocular hemodynamics assessment. Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2017;4(60):30-38. [In Russian].

8. Kiseleva T.N., Adzhemian N.A. Ocular blood flow assessment in vascular pathology of the eye. Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2015;2(58):24-31 [In Russian]

9. Sokolov O.V. The significance of ocular hemodynamics and visual function in the investigation of the diagnosis of the brachiocephalic arteries’ obstruction disease. Oftalmologisheskie vedomosti. 2010;3(3):63–70 [In Russian]

10. Flammer J., Konieczka K., Bruno R.M., Virdis A., Flammer A.J., Taddei S. The eye and the heart. Eur Heart J. 2013; 34(17):1270-1278.

11. Astakhov Y.S., Budnik V.M., Astakhov S.Y., Rukhovets A.G., Maklegin A.N., Akopov E.L. Calibration stand for ophthalmoplethysmograph. Patent for utility model RUS №160253. 2016

12. Bondarenko B.B., Bart V.A., Demchenko E.A. et al. Actual aspects of the methodology of clinical and statistical analysis. Clinical and experimental cardiology. Edited by Shlyakhto E.V. – SPb. :Publishing house:OOO «AMC», 2005. – P. 136-148

13. Rukhovets A.G. Astakhov Y.S.. Ophtalmoplethysmography in ocular blood flow assessment. Regionarnoe krovoobrashchenie i mikrocirkulyaciya. 2016; 2(58):17-23 [In Russian].

14. Flammer J., Konieczka K. Retinal venous pressure: the role of endothelin. The EPMA Journal. 2015;6(21):1-12