Morphological changes in the breast gland and ovary of mice with experimentally induced hyperthyroid condition

The frequency of breast tumors has been studied in inbreed C3H-A mice with affected thyroid status. It has been shown that frequency of breast tumors was significantly higher in the animals with hyperthyroid condition versus the hypothyroid group (р<0.01). The development of tumors was found on the 21, 29, and 36 weeks of the experiment for hyperthyroid, euthyroid, and hypothyroid, groups correspondingly. The frequency of breast tumors was 86.6, 62.5 and 30.0 % for hyperthyroid, euthyroid, and hypothyroid, correspondingly, at the end the experiment. Throughout the experiment the frequency of breast tumors in hypothyroid group was significantly lower as compared to the frequency of breast tumors in euthyroid and hyperthyroid as well. Morphological study elucidated the changes in ovary of mice with hyperthyroid status. The profound atrophic changes of the gland structures, absence of generative function, chronic inflammation, and development tubular adenoma were detected in the ovary of the hyperthyroid mice. In some animals the mammary glands were affected by malignant transformation characterized by development of glandular epithelial complexes as clear outlined tubes. It could be suggested that those tumors represent ductal adenocarcinoma. The data clear prove the idea that hyperthyroid condition triggers development of breast tumors.

гипертиреоз, рак молочной железы, мыши линии С3Н-А, hyperthyroid status, breast tumors, mice C3H-A

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