Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene
Abstract
Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid. Thirty days old flies treated with nicotinic acid showed better survival rate and reduced neurodegeneration.
About the Authors
O. I. Bolshakova
СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. Гатчина
Russian Federation
Russian Federation
D. I. Rodin
СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. Гатчина
Russian Federation
Russian Federation
S. I. Timoshenko
СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. Гатчина
Russian Federation
Russian Federation
E. M. Latypova
СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. Гатчина
Russian Federation
Russian Federation
S. V. Sarantseva
СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. Гатчина
Russian Federation
Russian Federation
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Review
For citations:
Bolshakova O.I., Rodin D.I., Timoshenko S.I., Latypova E.M., Sarantseva S.V. Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene. The Scientific Notes of the Pavlov University. 2013;20(3):14-17. (In Russ.)
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