Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg
https://doi.org/10.24884/1607-4181-2014-21-1-57-59
Abstract
Apolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship between (-75)G/A and 83C/T polymorphic variants of apolipoprotein A-I gene (APOA1) and the plasma lipid profile in the population of Saint-Petersburg. Allele T83 of APOA1 gene was found to be associated with the reduced risk of atherosclerosis development among Saint-Petersburg inhabitants. The study demonstrates that allele T83 of APOA1 gene is associated with higher plasma HDL cholesterol levels (p<0.02) and with reduced atherogenic ratio (p<0.02) in the population of Saint-Petersburg. Antiatherogenic role of allele T83 is related to the influence of 83C/T polymorphic variants of APOA1 gene on the plasma lipid profile.
About the Authors
V. V. Miroshnikova
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. Константинова
Russian Federation
Russian Federation
A. A. Panteleeva
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. Константинова
Russian Federation
Russian Federation
S. N. Pchelina
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. Константинова
Russian Federation
Russian Federation
A. L. Schwarzman
Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. Константинова
Russian Federation
Russian Federation
References
1. Климов А.Н., Никульчева Н.Г. Обмен липидов и ли-попротеинов и его нарушения. - СПб.: Питер Ком, 1999. -512 с.
2. Мирошникова В.В., Родыгина Т.И., Демина Е.П. и др. Ассоциации генетических вариантов апопротеина А-1 с развитием атеросклероза у жителей Санкт-Петербурга // Эколог. генетика. - 2010. - Т. 8 (2). - С. 24-28.
3. Abellan R., Mansego M.L., Martinez-Hervas S. et al. Dietary polyunsaturated fatty acids may increase plasma LDL-cholesterol and plasma cholesterol concentrations in carriers of an ABCG1 gene single nucleotide polymorphism: Study in two Spanish populations // Atherosclerosis. - 2011. - Vol. 219. -P. 900-906.
4. Curtiss L.K., Valenta D.T., Hime N.J., Rye K.A. What is so special about apolipoprotein AI in reverse cholesterol transport? // Arterioscler. Thromb. Vasc. Biol. - 2006. -Vol. 26. - P. 12-19.
5. Franca 1 Е., Alves J.G.B., Hutz M.H. et al. APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children // Brazilian Journal of Medical and Biological Research. - 2005. -Vol. 38. - P. 535-541.
6. Gomez P., Perez-Martinez P., Marin C. et al. APOA1 and APOA4 gene polymorphisms influence the effects of dietary fat on LDL particle size and oxidation in healthy young adults // J. Nutr. - 2010. - Vol. 140. -P. 773-778.
7. Hamon S.C., Kardia S.L., Boerwinkle E. et al. Evidence for consistent intragenic and intergenic interactionsbetween SNP effects in the APOA1/C3/A4/A5 gene cluster // Human Heredity. -2006. - Vol. 61(2). - P. 87-96.
8. Hovingh G.K., de Groot E., van der Steeg W. et al. Inherited disorders of HDL metabolism and atherosclerosis // Curr. Opin. Lipidol. - 2005. - Vol. 16 (2). - P. 139- 145.
9. Juo S.H., Wyszynski D.F., Beaty T.H. et al. Mild association between the A/G polymorphism in the promoter of apolipoprotein A-I gene and apolipoprotein A-I levels: a metaanalysis // American Journal of Medical Genetics. - 1999. -Vol. 82 (3). - P. 235-241.
10. Kamboh M.I., Aston C.E., Nestlerode C.M. et al. Haplotype analysis of two APOA1/MspI polymorphisms in relation to plasma levels of apo A-I and HDL-cholesterol // Atherosclerosis. -1996. - Vol. 127 (2). - P. 255-262.
11. Li Q., Yin R.-X., Wei X.-L. et al. ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels // PLoS ONE. - 2012. -Vol. 7(5). - P. e37972.
12. Moradian A.D., Haas M.J., Wong N.C.W. The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels // Endocrine Reviews. - 2006. -№ 27. - P. 2-16.
13. Padmaja N., Ravindra Kumar M., Adithan C. et al. Association of polymorphisms in apolipoprotein A1 and apolipoprotein B genes with lipid profile in Tamilian population // Indian Heart Journal. - 2009. - Vol. 61. - P. 51-54.
14. Pagani F., Giudici G.A., Baralle F.E. et al. Association of a polymorphism in the Apo AI gene promoter with hyperalpha-lipoproteinemia // European Journal of Epidemiology. - 1992. -Vol. 8 (1). - P. 54-58.
15. Pulkkinen A., Viitanen L., Kareinen A. et al. MspI polymorphism at +83 bp in intron 1 of the human apolipoprotein A1 gene is associated with elevated levels of HDL cholesterol and apolipoprotein A1 in nondiabetic subjects but not in type 2 diabetic subjects with coronary heart disease // Diabetes Care. - 2000. - Vol. 23(6). - P. 791-795.
16. Wang X.L., Badenhop R.B., Sim A.S. et al. The effect on transcription efficiency of the apolipoprotein AI gene of DNA variants at the 5' untranslated region // International Journal of Clinical and Laboratory Research. - 1998. - Vol. 28 (4). -P. 235-241.
17. Zou Y., Hu D., Yang X. et al.Relationships among apolipoprotein A1 gene polymorphisms, lipid levels and coronary atherosclerosis disease // Chinese Medical Journal. - 2003. -Vol. 116 (5). - P. 665-668.
Review
For citations:
Miroshnikova V.V., Panteleeva A.A., Pchelina S.N., Schwarzman A.L. Association of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-Petersburg. The Scientific Notes of the Pavlov University. 2014;21(1):57-59. (In Russ.) https://doi.org/10.24884/1607-4181-2014-21-1-57-59
Views:
1003
Email this article 