Protein markers of mitochondria formation and alteration in patients with impaired blood circulation

Patients with abnormal left ventricular outflow tract had middle lactic acidemia with detected cytochrome C release into the bloodstream and liberation of protein PGC1a (peroxisome proliferator-activated receptor gamma coactivator-1alpha) with elevation its blood concentration reflecting mitochondrial biogenesis in tissues.

PGC1a, цитохром С, молочная кислота, пировиноградная кислота, диагностика митохондриальной дисфункции, PGC1a, cytochrome C, lactic acid, pyruvic acid, diagnostics of mitochondrial dysfunction

1. Алексеевская Е.С., Жлоба А.А., Субботина Т.Ф. Ультрафильтрация в преаналитической стадии при определении концентрации молочной кислоты в плазме крови // Клин. лаборатор. диагностика. - 2013. - № 11. - С. 27-31.

2. Жлоба А.А., Маевская Е.Г. Дисфункция анаплероти-ческого пути энергетического метаболизма от аминокислот к сукцинату у лиц старшей возрастной группы // Артериальная гипертензия. - 2011. - № 1. - С. 74-78.

3. Aquilano K., Vigilanza P., Baldelli S. et al. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis // J. Biol. Chem. - 2010. - № 28. - P. 21590 - 21599.

4. Austin S., St-Pierre J. PGC16 and mitochondrial metabolism: emerging concepts and relevance in ageing and neurodegenerative disorders // J. Cell Sci. - 2012. - Vol. 125 (Pt 21). - P. 4963-4971.

5. Chang J.S., Huypens P., Zhang Y. et al. Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1 // J. Biol. Chem. - 2010. - № 23. - Р. 18039-18050.

6. Coleman R., Silbermann M., Gershon D. et al. Giant mitochondria in the myocardium of aging and endurance-trained mice // Gerontology. - 1987. - № 1. - P. 34-39.

7. Dillon L.M., Rebelo A.P., Moraes C.T. The role of PGC-1 coactivators in aging skeletal muscle and heart // IUBMB Life. - 2012. - № 3. - P. 231-241.

8. Finck B.N., Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease // J. Clin. Invest. - 2006. - № 3. - P. 615-622.

9. Horan M.P., Pichaud N., Ballard J.W. Review: quantifying mitochondrial dysfunction in complex diseases of aging // J. Gerontol. A Biol. Sci. Med. Sci. - 2012. - № 10. - P. 1022-1035.

10. Kokawa K., Shikone T., Nakano R. Apoptosis in the human uterine endometrium during the menstrual cycle // J. Clin. Endocrinol. Metab. - 1996. - № 11. - P. 4144-4147.

11. Kozlov A.V., Bahrami S., Calzia E. et al. Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure? // Annals of Intensive Care. - 2011. - № 1. -P. e41.

12. Liesa M., Palacin M., Zorzano A. Mitochondrial dynamics in mammalian health and disease // Physiol. Rev. - 2009. -№ 3. - P. 799-845.

13. Ogasawara E., Nakada K., Hayashi J. Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion // Hum. Mol. Genet. - 2010. - № 16. - P. 3179-3189.

14. Radhakrishnan J., Wang S., Ayoub I.M. et al. Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survival // Am. J. Physiol. Heart Circ. Physiol. - 2007. - № 2. - P. H767-H775.

15. Sano M., Tokudome S., Shimizu N. et al. Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor y coactivator 1a // J. Biol. Chem. - 2007. - № 35. -P. 25970-25980.

16. Skulachev V.P. What is «phenoptosis» and how to fight it? // Biochemistry (Moscow). - 2012. - № 7. -P. 689-706.

17. Zorov D.B., Plotnikov E.Y., Jankauskas S.S. et al. The Phenoptosis problem: what is causing the death of an organism? Lessons from acute kidney injury // Biochemistry (Moscow). - 2012. - № 7. - P. 742-753.