Influence of AB0-incompatibility on complications occurrence after allogeneic hematopoietic stem cell transplantation
https://doi.org/10.24884/1607-4181-2015-22-1-57-59
Abstract
Research objective: To assess the impact of AB0 erythrocyte antigens system incompatibility on complications incidence after allogeneic hematopoietic stem cell transplantation (alloHSCT). Patients and methods. The study included 240 patients - recipients for alloHSCT with oncological and hematological diseases. The median age was 19.0 (1-66) years. The research revealed that overall incidence of acute graft-versus-host disease (aGVHD) was higher in the case of AB0-incompatibiIity (p <0.01), and the rate of aGVHD severe forms at AB0-incompatible alloHSCT were observed more often (p = 0.005). At AB0-inco-mpatible unrelative alloHSCT risk of aGVHD was higher (81,3 %) compared to the relative alloHSCT (44 %) (p = 0.002). AB0-incompatibility between donor of HSC and the recipient may be a risk factor for aGVHD.
About the Authors
M. A. Kucher
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
M. A. Estrina
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
S. N. Bondarenko
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
N. E. Ivanova
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
A. L. Alyansky
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
B. V. Afanasyev
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Kucher M.A., Estrina M.A., Bondarenko S.N., Ivanova N.E., Alyansky A.L., Afanasyev B.V. Influence of AB0-incompatibility on complications occurrence after allogeneic hematopoietic stem cell transplantation. The Scientific Notes of the Pavlov University. 2015;22(1):57-59. (In Russ.) https://doi.org/10.24884/1607-4181-2015-22-1-57-59
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