The use of the results of multiplex analysis of the morphological substrate of the tumor in the differential diagnosis of pigmented and non-pigmented superficial melanomas of the skin using the example of two clinical observations
A. V. Borisov,
I. A. Chernov,
V. E. Rodionov,
A. M. Avdalyan,
D. N. Protsenko,
A. I. Nichiporov,
V. I. Kukushkin,
Yu. A. Kirillov https://doi.org/10.24884/1607-4181-2024-31-1-62-69
Abstract
Observations of pigmented (melanoblastic) and non-pigmented (achromatic) superficial melanomas of the skin are described, for the differential diagnosis of which, along with traditional histological examination, precision (immunohistochemical, molecular genetic) methods of studying the morphological substrate of the tumor were used. Based on the results of Raman spectroscopy of samples of both tumors, their multiplex analysis was carried out, with the help of which a significant number of molecules of various analytes were simultaneously identified in one individual sample of a biological object.
About the Authors
A. V. Borisov
Tyumen State Medical University
Russian Federation
Competing Interests:
Russian Federation
Borisov Alexey V., Applicant of the Department of Pathological Anatomy and Forensic Medicine
Tyumen
Competing Interests:
Authors declare no conflict of interes
I. A. Chernov
Tyumen State Medical University
Russian Federation
Competing Interests:
Russian Federation
Chernov Igor A., Cand. of Sci. (Med.), Associate Professor, Head of the Department of Pathological Anatomy and Forensic Medicine
Tyumen
Competing Interests:
Authors declare no conflict of interes
V. E. Rodionov
Moscow Multidisciplinary Clinical Center «Kommunarka»
Russian Federation
Competing Interests:
Russian Federation
Rodionov Vladimir E., Pathologist
Moscow
Competing Interests:
Authors declare no conflict of interes
A. M. Avdalyan
Moscow Multidisciplinary Clinical Center «Kommunarka»
Russian Federation
Competing Interests:
Russian Federation
Avdalyan Ashot M., Dr. of Sci. (Med.), Head of the Pathological Department
Moscow
Competing Interests:
Authors declare no conflict of interes
D. N. Protsenko
Moscow Multidisciplinary Clinical Center «Kommunarka»
Russian Federation
Competing Interests:
Russian Federation
Protsenko Denis N., Dr. of Sci. (Med.), Director
Moscow
Competing Interests:
Authors declare no conflict of interes
A. I. Nichiporov
Moscow Multidisciplinary Clinical Center «Kommunarka»
Russian Federation
Competing Interests:
Russian Federation
Nichiporov Andrey I., Employee
Moscow
Competing Interests:
Authors declare no conflict of interes
V. I. Kukushkin
Osipyan Institute of Solid State Physics RAS
Russian Federation
Competing Interests:
Russian Federation
Kukushkin Vladimir I., Cand. of Sci. (Phys.-Math.), Senior Research Fellow of the Laboratory of Non-equilibrium Electronic Processes
Chernogolovka
WoS ResearcherID: P-4776-2015, Scopus AuthorID: 5586675800
Competing Interests:
Authors declare no conflict of interes
Yu. A. Kirillov
Tyumen State Medical University; Moscow Multidisciplinary Clinical Center «Kommunarka»; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution «Petrovsky National Research Centre of Surgery»
Russian Federation
Competing Interests:
Russian Federation
Kirillov Yuri A., Dr. of Sci. (Med.), Professor, Pathologist; Professor of the Department of Pathological Anatomy and Forensic Medicine; Leading Research Fellow
8, Sosensky Stan str., Kommunarka, Moscow, 108814
Competing Interests:
Authors declare no conflict of interes
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Borisov A.V., Chernov I.A., Rodionov V.E., Avdalyan A.M., Protsenko D.N., Nichiporov A.I., Kukushkin V.I., Kirillov Yu.A. The use of the results of multiplex analysis of the morphological substrate of the tumor in the differential diagnosis of pigmented and non-pigmented superficial melanomas of the skin using the example of two clinical observations. The Scientific Notes of the Pavlov University. 2024;31(1):62-69. (In Russ.) https://doi.org/10.24884/1607-4181-2024-31-1-62-69
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