Systemic inflammation in salivary gland cancer
https://doi.org/10.24884/1607-4181-2022-29-3-74-80
Abstract
Relevance. The inflammatory process and endogenous intoxication of the patient’s body has a negative impact on the course of many malignant neoplasms, including salivary gland cancer.
The objective of the study was to determine the influence of some factors of systemic inflammation and endogenous intoxication in salivary gland cancer.
Methods and materials. A prospective study included the data of 59 patients with salivary gland cancer. The influence of peripheral blood parameters and relative indicators characterizing systemic inflammation on overall and disease-free survival was assessed.
Results. As a result of the multivariate analysis, it was revealed that an increase in the level of the relative number of peripheral blood neutrophils by more than 60.08 % increases the risk of death in patients from salivary gland cancer by 3.90 times (p=0.0456; HR 3.90: 95 % CI 1.03–14.79). The level of the absolute number of peripheral blood lymphocytes, not exceeding 1.49x109 /l, increases the risk of disease progression by 8.72 times (p=0.0002, R 8.72: 95 % CI 2.78–27.28).
Conclusion. Individual factors of systemic inflammation and endogenous intoxication, it is advisable to evaluate at the stage of planning the primary treatment of patients with salivary gland cancer, in order to determine the prognosis of the disease and optimize the choice of tactics for the primary treatment of patients.
About the Authors
S. I. Kutukova
Pavlov University;
City Clinical Oncology Center
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor of the Department of Dentistry and Maxillofacial Surgery, 6-8, L’va Tolstogo str., Saint Petersburg, 197022;
Oncologist of the Department № 10 (Antitumor Drug Therapy), Saint Petersburg
N. P. Belyak
Pavlov University;
St Petersburg University
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor of the Department of Oncology of the Faculty of Medicine, 6-8, L’va Tolstogo str., Saint Petersburg, 197022;
Oncologist, Head of the Department № 10 (Antitumor Drug Therapy), Saint Petersburg
J. V. Ivaskova
Pavlov University;
City Clinical Oncology Center
Russian Federation
Russian Federation
Assistant of the Department of Dentistry and Maxillofacial Surgery, 6-8, L’va Tolstogo str., Saint Petersburg, 197022;
Oncologist of the Department № 7 (Head and Neck Tumors), Saint Petersburg
A. Ya. Razumova
Pavlov University
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor of the Department of Dentistry and Maxillofacial Surgery,
6-8, L’va Tolstogo str., Saint Petersburg, 197022
N. V. Pakhomova
Pavlov University
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Associate Professor of the Department of Dentistry and Maxillofacial Surgery,
6-8, L’va Tolstogo str., Saint Petersburg, 197022
N. A. Frolov
Pavlov University
Russian Federation
Russian Federation
Frolov Nikolai A., Cand. of Sci. (Med.), Associate Professor of the Department of Dentistry and Maxillofacial
Surgery,
6-8, L’va Tolstogo str., Saint Petersburg, 197022
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Review
For citations:
Kutukova S.I., Belyak N.P., Ivaskova J.V., Razumova A.Ya., Pakhomova N.V., Frolov N.A. Systemic inflammation in salivary gland cancer. The Scientific Notes of the Pavlov University. 2022;29(3):74-80. (In Russ.) https://doi.org/10.24884/1607-4181-2022-29-3-74-80
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