ОСОБЕННОСТИ ВЛИЯНИЯ РАЗЛИЧНЫХ ФОРМ ВИТАМИНА D НА КОСТНО-СУСТАВНУЮ СИСТЕМУ

Витамин D принимает участие в метаболизме костной ткани, регулируя процессы минерализации и ремоделирования. Имеются многочисленные сведения об использовании витамина D у больных травматолого-ортопедического профиля, однако мнения о способе введения, дозах, эффективности весьма разнятся и требуют более углубленного изучения.

Цель работы состояла в проведении обзора и анализа актуальных клинических и экспериментальных исследований, связанных с изучением влияния метаболитов витамина D при эндопротезировании крупных суставов, среди доступных медицинских источников баз данных PubMed, Cohraine, e-Library.

Результаты большинства исследований местного и системного использования метаболитов витамина D позволяют сделать вывод о благотворном влиянии данных соединений на регенерацию костной ткани в травматологии и ортопедии. Тем не менее для однозначного определения возможностей клинического применения обозначенных подходов необходимы дальнейшие исследования.

Мы предполагаем, что в перспективных работах следует учитывать следующие факторы: оценка долгосрочного эффекта и использование стандартизованных доз, изучение новых производных витамина D, синергизма в комбинациях препаратов витамина D, фармакокинетики препаратов витамина D и полиморфизмов генов, ассоциированных с витамином D, и генов, влияющих на жизнедеятельность костной ткани, а также оценка влияния сопутствующих заболеваний и системных патологических процессов на метаболизм витамина D и восстановление костной ткани. Также мы определяем одновременную коррекцию уровней витамина D как важную составляющую компенсации костных нарушений у травматологических и ортопедических пациентов. 

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