Role of galectin 3 and epicardial fat thickness in the development of atrial fibrillation in patients with metabolic syndrome
https://doi.org/10.24884/1607-4181-2015-22-1-43-46
Abstract
Objective. To evaluate the epicardial fat thickness (EFT) in patients with metabolic syndrome (MS), including paroxysmal and persistent atrial fibrillation (AF). To relate EFT to the fibroid heart marker, i.e. galectin 3. Materials and methods. We examined 100 patients with MS (50 with AF), and 50 healthy persons made the control group. Serum galectin 3 was measured by ELISA method. The EFT was measured with echocardiography. Results. EFT in patients with MS was twofold higher than in healthy persons. EFT in patients with MS and AF didn't differ significantly from that in patients with MS without AF. Positive correlation between the levels of EFT and galectin 3 in serum was revealed. Serum galectin 3 and EFT were associated with atrial fibrillation in patients with MS (OR:1,27, 95% CI 1,02-1,58 and OR:1,73, 95% CI 1,37-2,19, correspondingly).Conclusion. Definition of EFT at echocardiography can be used in the assessment of risk AF in patients with MS.
About the Authors
V. A. Ionin
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
O. V. Listopad
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
S. E. Nifontov
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
E. I. Baranova
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
A. V. Soboleva
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
E. V. Shlyakhto
Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Ionin V.A., Listopad O.V., Nifontov S.E., Baranova E.I., Soboleva A.V., Shlyakhto E.V. Role of galectin 3 and epicardial fat thickness in the development of atrial fibrillation in patients with metabolic syndrome. The Scientific Notes of the Pavlov University. 2015;22(1):43-46. (In Russ.) https://doi.org/10.24884/1607-4181-2015-22-1-43-46
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