uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2015-22-2-60-63uzspbgmu-95Research ArticleОРГАНИЗАЦИЯ ЗДРАВООХРАНЕНИЯHEALTH CARE ORGANIZATIONПОЛИМОРФИЗМ S19W ГЕНА АПОЛИПОПРОТЕИНА А5 У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 2 ТИПА - СВЯЗЬ С МЕТАБОЛИЧЕСКИМИ ПАРАМЕТРАМИ И УРОВНЕМ ТРИГЛИЦЕРИДОВPolymorphism of S19W of apolipoprotein A5gene in patients with type 2 diabetes mellitus - connection with metabolic parameters and triglyceride levelsСкорюковаС. А.SkoryukovaS. A.noemail@neicon.ruКимМ. В.KimM. V.noemail@neicon.ruБыстроваА. А.BystrovaA. A.noemail@neicon.ruБабенкоА. Ю.BabenkoA. Yu.noemail@neicon.ruБарановаЕ. И.BaranovaE. I.noemail@neicon.ruПчелинаС. Н.PchelinaS. N.noemail@neicon.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Северо-Западный федеральный медицинский исследовательский центрРоссия2015300620152226063Copyright © Скорюкова С.А., Ким М.В., Быстрова А.А., Бабенко А.Ю., Баранова Е.И., Пчелина С.Н., 20152015Скорюкова С.А., Ким М.В., Быстрова А.А., Бабенко А.Ю., Баранова Е.И., Пчелина С.Н.Skoryukova S.A., Kim M.V., Bystrova A.A., Babenko A.Y., Baranova E.I., Pchelina S.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/95

В статьерассматриваются генетические аспекты влияния полиморфных вариантов гена S19W аполипопротеина А5 на липидный спектр крови у больных сахарным диабетом 2 типа, а также влияние различных клинико-анамнестических параметров на показатели липидного спектра крови, определяющих развитие атерогенной дислипидемии. Выявлена взаимосвязь развития гипертриглицедемии с носительством аллеля 19W у больных сахарным диабетом 2 типа.

The article deals with genetic aspects of the influence of S19W polymorphic variants of apolipoprotein A5 gene, on the blood lipids in patients with type 2 diabetes mellitus, as well as influence of various clinical and anamnestic parameters on the blood lipids determining the development f atherogenic dyslipidemia.. The study revealed interrelation between 19W allele and hypertriglyceridemia development in patients with type 2 diabetes mellitus.

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The authors declare that there are no conflicts of interest present.