uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2021-28-1-17-22uzspbgmu-795Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESАпикальная гипертрофическая кардиомиопатия: современные представления о распространенности, клинической картине, диагностике и лечении (обзор литературы)Apical hypertrophic cardiomyopathy: contemporary view on the prevalence, clinical profile, diagnostic and treatmen (review of literature)https://orcid.org/0000-0002-2766-8946СтрельцоваА. А.StreltsovaA. A.

Стрельцова Анна Алексеевна - врач ультразвуковой диагностики.Санкт-Петербург.

Streltsova Anna A. - Ultrasound Specialist, Almazov National Medical Research Centre.Saint Petersburg.

anikas1985@gmail.comhttps://orcid.org/0000-0003-0156-8821ГудковаА. Я.GudkovaA. Ya.

Гудкова Александра Яковлевна - доктор медицинских наук, заведующая лабораторией кардиомиопатий Института сердечно-сосудистых заболеваний Научно-клинического исследовательского центра, профессор кафедры факультетской терапии, ПСПбГМУ им. акад. И.П. Павлова; ведущий научный сотрудник Института молекулярной биологии и генетики, НМИЦ им. В.А. Алмазова.197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

Gudkova Aleksandra Ya. - Dr. of Sci. (Med.), Head of the Laboratory of Cardiomyopathies of the Institute of Cardiovascular Diseases of the Scientific and Clinical Research Center, Professor of the Department of Faculty Therapy, Pavlov University; Leading Research Fellow at the Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre.6-8, L'va Tolstogo str., Saint Petersburg, 197022.

alexagood-1954@mail.ruНациональный медицинский исследовательский центр имени В.А. Алмазова Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationНациональный медицинский исследовательский центр имени В.А. Алмазова Министерства здравоохранения Российской Федерации; Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre; Pavlov UniversityRussian Federation2021210120212811722Copyright © Стрельцова А.А., Гудкова А.Я., 20212021Стрельцова А.А., Гудкова А.Я.Streltsova A.A., Gudkova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/795

Представлен обзор данных литературы, посвященных распространенности, особенностям клинического течения, диагностике и лечению апикальной гипертрофической кардиомиопатии (ГКМП) как наименее изученному варианту ГКМП. Особое внимание уделяется редкой форме апикальной ГКМП — среднежелудочковой гипертрофической кардиомиопатии, осложненной развитием верхушечной аневризмы.

This review presents the last literature data, concerning prevalence, clinical profile, diagnostic and treatment of apical hypertrophic cardiomyopathy (HCM), as less known among «classical» variants of HCM. It is also discussed the rare form of apical HCM — mid-ventricular HCM with apical aneurism formation.

 

апикальная гипертрофическая кардиомиопатиясреднежелудочковая гипертрофическая кардиомиопатияобструкция левого желудочка на срединном уровневерхушечная аневризмаapical hypertrophic cardiomyopathymid-ventricular hypertrophic cardiomyopathyleft ventricular obstruction at the median levelapical aneurismReferencesElliott P. M., Anastasakis A., Borger M. A. et al. ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC) // European Heart Journal. -2014. - Vol. 35, № 39. - Р 2733-2779. Doi: 10.1093/eurheartj/ehu284.Elliott P. M., Anastasakis A., Borger M. A., Borggrefe M., Cecchi F., Charron P., Hagege A. A., Lafont A., Limongelli G., Mahrholdt H., McKenna W. J., Mogensen J., Nihoyannopoulos P., Nistri S., Pieper P. G., Pieske B., Rapezzi C., Rutten F. H., Tillmanns C., Watkins H. ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC) // European Heart Journal. 2014;35(39):2733-2779. Doi: 10.1093/eurheartj/ehu284.Liu Q., Li D., Berger A. E. et al. Survival and prognostic factors in hypertrophic cardiomyopathy: a meta-analysis // Scientific Reports. - 2017. - Vol. 7, № 1. - Р. 11957. Doi: 10.1038/s41598-017-12289-4.Liu Q., Li D., Berger A. E., Johns R. A., Gao L. Survival and prognostic factors in hypertrophic cardiomyopathy: a meta-analysis // Scientific Reports. 2017;7(1):11957. Doi: 10.1038/s41598-017-12289-4.Becker R. C., Owens A. P. 3rd, Sadayappan S. Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy // Journal of Thrombosis and Thrombolysis. - 2020. - Vol. 49, № 2. - Р. 177-183. Doi: 10.1007/s11239-019-02026-1.Becker R. C., Owens A. P. 3rd, Sadayappan S. Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy // Journal of Thrombosis and Thrombolysis. 2020;49(2):177-183. Doi: 10.1007/s11239-019-02026-1.Kitaoka H., Doi Y., Casey S. A. et al. Comparison of prevalence of apical hypertrophic cardiomyopathy in Japan and the United States // American Journal of Cardiology. -2003. - Vol. 92, № 10. - Р. 1183-1186. Doi: 10.1016/j.am-jcard.2003.07.027.Kitaoka H., Doi Y., Casey S. A., Hitomi N., Furuno T., Maron B. J. Comparison of prevalence of apical hypertrophic cardiomyopathy in Japan and the United States // American Journal of Cardiology. 2003;92(10):1183-1186. Doi: 10.1016/j.amjcard.2003.07.027.Moon J., Shim C. Y., Ha J. W. et al. Clinical and echocardiographic predictors of outcomes in patients with apical hypertrophic cardiomyopathy // American Journal of Cardiology. - 2011. - Vol. 108, № 11. - Р 1614-1619. Doi: 10.1016/j.amjcard.2011.07.024.Moon J., Shim C. Y., Ha J. W., Cho I. J., Kang M. K., Yang W. I., Jang Y., Chung N., Cho S. Y. Clinical and echocardiographic predictors of outcomes in patients with apical hypertrophic cardiomyopathy // American Journal of Cardiology. 2011;108(11):1614-1619. Doi: 10.1016/j.amj-card.2011.07.024.Kubo T., Kitaoka H., Okawa M. et al. Clinical profiles of hypertrophic cardiomyopathy with apical phenotype-comparison of pure-apical form and distal-dominant form // Circulation Journal. - 2009. - Vol. 73, № 12. - Р. 2330-2336. Doi: 10.1253/circj.cj-09-0438.Kubo T., Kitaoka H., Okawa M., Hirota T., Hoshikawa E., Hayato K., Yamasaki N., Matsumura Y., Yabe T., Nishinaga M., Takata J., Doi Y. L. Clinical profiles of hypertrophic cardiomyopathy with apical phenotype-comparison of pure-apical form and distal-dominant form // Circulation Journal. 2009 ;73(12): 2330-2336. Doi: 10.1253/circj.cj-09-0438Apical hypertrophic cardiomyopathy: Present status / M. F. Jan, M. C. Todaro, L. Oreto, A. J. Tajik // Int. J. of Cardiology. 2016. - № 222. - Р. 745-759. Doi: 10.1016/j.ijcard.2016.07.154.Jan M. F., Todaro M. C., Oreto L., Tajik A. J. Apical hypertrophic cardiomyopathy: Present status // International Journal of Cardiology. 2016;222:745-759. Doi: 10.1016/j.ijcard.2016.07.154.Maron B. J., McKenna W. J., Danielson G. K. et al. ACC/ESC Expert Consensus Document on Hypertrophic Cardiomyopathy // Journal of the American College of Cardiology. - 2003. - Vol. 42, № 9. - Р. 1687-1713. Doi: 10.1016/S0735-1097(03)00941-0.Maron B. J., McKenna W. J., Danielson G. K., Kappenberger L. J., Kuhn H. J., Seidman C. E., Torbicki A. ACC/ ESC Expert Consensus Document on Hypertrophic Cardiomyopathy // Journal of the American College of Cardiology. 2003;42(9):1687-1713. Doi: 10.1016/S0735-1097(03)00941-0.Maron B. J., Ommen S. R., Semsarian C. et al. Hypertrophic cardiomyopathy: Present and future, with translation into contemporary cardiovascular medicine // J. of the Am. College of Cardiology. - 2014. - Vol. 64, № 1. - Р. 83-99. Doi: 10.1016/j.jacc.2014.05.003.Maron B.J., Ommen S.R., Semsarian C, Spirito P., Ol-ivotto I., Maron M.S. Hypertrophic cardiomyopathy: Present and future, with translation into contemporary cardiovascular medicine // Journal of the American College of Cardiology. 2014;64(1):83-99. DOI:10.1016/j.jacc.2014.05.003.Maron M. S., Finley J. J., Bos J. M. et al. Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy // Circulation. - 2008. - Vol. 118, № 15. - Р. 1541-1549. Doi: 10.1161/CIRCULATIONAHA.108.781401.Maron M. S., Finley J. J., Bos J. M., Hauser T. H., Manning W. J., Haas T .S., Lesser J. R., Udelson J. E., Ackerman M. J., Maron B. J. Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy // Circulation. 2008;118(15):1541-1549. Doi: 10.1161/CIRCULATIONAHA.108.781401.Cui L., Tse G., Zhao Z. et al. Mid-ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm: An important subtype of arrhythmogenic cardiomyopathy // Annals of Noninvasive Electrocardiology. - 2019. - Vol. 24, № 5. - Р. e12638. Doi: 10.1111/anec.12638.Cui L., Tse G., Zhao Z., Bazoukis G., Letsas K. P., Korantzopoulos P., Roever L., Li G., Liu T.. Mid-ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm: An important subtype of arrhythmogenic cardiomyopathy // Annals of Noninvasive Electrocardiology. 2019; 24(5):e12638. Doi: 10.1111/anec.12638.Cai C., Duan F. J., Yang Y. J. et al. Comparison of the prevalence, clinical features, and long-term outcomes of midventricular hypertrophy vs apical phenotype in patients with hypertrophic cardiomyopathy // Canadian J. of Cardiology. - 2014. - Vol. 30, № 4. - Р. 441-447. Doi: 10.1016/j.cjca.2013.10.005.Cai C., Duan F. J., Yang Y. J., Guo X., Liu Y. L., Liu Y. Q., Yan L. R., Xu Z. M., Zhao S. H., Hua W., Li Y. S., Fan C. M. Comparison of the prevalence, clinical features, and long-term outcomes of midventricular hypertrophy vs apical phenotype in patients with hypertrophic cardiomyopathy // Canadian Journal of Cardiology. 2014;30(4):441-447. Doi: 10.1016/j.cjca.2013.10.005.Tengiz, I., Ercan, E., Turk U. O. Percutaneous myocardial ablation for left mid-ventricular obstructive hypertrophic cardiomyopathy // Int. J. of Cardiovascular Imaging. - 2006. -Vol. 22, № 1. - Р. 13-18. Doi: 10.1007/s10554-005-5295-8.Tengiz I., Ercan E., Turk U. O. Percutaneous myocardial ablation for left mid-ventricular obstructive hypertrophic cardiomyopathy // International Journal of Cardiovascular Imaging. 2006;22(1):13-18. Doi: 10.1007/s10554-005-5295-8.Tse H. F., Ho H. H. Sudden cardiac death caused by hypertrophic cardiomyopathy associated with midventricular obstruction and apical aneurysm // Heart. - 2003. - Vol. 89, № 2. - Р. 178. Doi: 10.1136/heart.89.2.178.Tse H. F., Ho H. H. Sudden cardiac death caused by hypertrophic cardiomyopathy associated with midventricular obstruction and apical aneurysm // Heart. 2003;89(2):178. Doi: 10.1136/heart.89.2.178.Towe E. C., Bos J. M., Ommen S. R. et al. Genotype-phenotype correlations in apical variant hypertrophic cardiomyopathy // Congenital Heart Disease. - 2015. -Vol. 10, № 3. - Р. E139-E145. Doi: 10.1111/chd.12242.Towe E. C., Bos J. M., Ommen S. R., Gersh B. J., Ackerman M. J. Genotype-phenotype correlations in apical variant hypertrophic cardiomyopathy // Congenital Heart Disease. 2015;10(3):E139-E145. Doi: 10.1111/chd.12242.Matsubara K., Nakamura T., Kuribayashi T. et al. Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy // J. of the Am. College of Cardiology. - 2003. - Vol. 42, № 2. - Р. 288-295. Doi: 10.1016/s0735-1097(03)00576-x.Matsubara K., Nakamura T., Kuribayashi T., Azuma A., Nakagawa M. Sustained cavity obliteration and apical aneurysm formation in apical hypertrophic cardiomyopathy // Journal of the American College of Cardiology. 2003;42(2):288-295. Doi: 10.1016/s0735-1097(03)00576-x.Minami Y., Kajimoto K., Terajima Y. et al. Clinical implications of midventricular obstruction in patients with hypertrophic cardiomyopathy // J. of the Am. College of Cardiology. - 2011. - Vol. 57, № 23. - Р. 2346-2355. Doi: 10.1016/j.jacc.2011.02.033.Minami Y., Kajimoto K., Terajima Y., Yashiro B., Okayama D., Haruki S., Nakajima T., Kawashiro N., Kawana M., Hagiwara, N. Clinical implications of midventricular obstruction in patients with hypertrophic cardiomyopathy // Journal of the American College of Cardiology. 2011; 57(23):2346-2355. Doi: 10.1016/j.jacc.2011.02.033.Pivatto Jr. F., Mossmann M., Krepsky A. M. et al. Mid-Ventricular Hypertrophic Obstructive Cardiomyopathy // Revista Brasileira de Cardiologia Invasiva. - 2014. - Vol. 22, № 2. - Р. 180-182. Doi: 10.1590/0104-1843000000030.Pivatto Jr.F., Mossmann M., Krepsky A.M., Zago A. Mid-Ventricular Hypertrophic Obstructive Cardiomyopathy // Revista Brasileira de Cardiologia Invasiva. 2014;22(2);180-182. Doi: 10.1590/0104-1843000000030.Cui L., Suo Y., Zhao Y. et al. Mid-Ventricular Obstructive Hypertrophic Cardiomyopathy and Apical Aneurysm Mimicking Acute ST-Elevation Myocardial Infarction // Annals of Noninvasive Electrocardiology. - 2016. - Vol. 21, № 1. - Р. 98-101. Doi: 10.1111/anec.12284.Cui L., Suo Y., Zhao Y., Li G., Liu T. Mid-Ventricular Obstructive Hypertrophic Cardiomyopathy and Apical Aneurysm Mimicking Acute ST-Elevation Myocardial Infarction // Annals of Noninvasive Electrocardiology. 2016;21(1):98-101. Doi: 10.1111/anec.12284MornerS., Johansson B., Henein M. Arrhythmogenic left ventricular apical aneurysm in hypertrophic cardiomyopathy // Int. Journal of Cardiology. - 2011. - Vol. 151, № 1. -Р. e8-e9. Doi: 10.1016/j.ijcard.2010.02.071.Morner S., Johansson B., Henein M. Arrhythmogenic left ventricular apical aneurysm in hypertrophic cardiomyopathy // International Journal of Cardiology. 2011;151(1):e8-e9. Doi: 10.1016/j.ijcard.2010.02.071Dilaveris P., Aggeli, C., Synetos A. et al. Sustained ventricular tachycardia as a first manifestation of hypertrophic cardiomyopathy with mid-ventricular obstruction and apical aneurysm in an elderly female patient // Annals of Noninvasive Electrocardiology. - 2017. - Vol. 22, № 3. - Р. e12422. Doi: 10.1111/anec.12422.Dilaveris P., Aggeli, C., Synetos A., Skiadas, I., Antoniou C.K., Tsiamis E., Tousoulis D. Sustained ventricular tachycardia as a first manifestation of hypertrophic cardiomyopathy with mid-ventricular obstruction and apical aneurysm in an elderly female patient // Annals of Noninvasive Electrocardiology. 2017;22(3):e12422. Doi: 10.1111/anec.12422.Perez-Riera A. R., Barbosa-Barros R., de Lucca A. A. et al. Mid-ventricular Hypertrophic Obstructive Cardiomyopathy with Apical Aneurysm Complicated with Syncope by Sustained Monomorphic Ventricular Tachycardia // Annals of Noninvasive Electrocardiology. - 2016. - Vol. 21, № 6. -Р. 618-621. Doi: 10.1111/anec.12377.Pёrez-Riera A. R., Barbosa-Barros R., de Lucca A. A., Viana M. J., de Abreu L. C. Mid-ventricular Hypertrophic Obstructive Cardiomyopathy with Apical Aneurysm Complicated with Syncope by Sustained Monomorphic Ventricular Tachycardia // Annals of Noninvasive Electrocardiology. 2016;21(6):618-621. Doi: 10.1111/anec.12377.Sato Y., Matsumoto N., Matsuo S. et al. Mid-ventricular hypertrophic obstructive cardiomyopathy presenting with acute myocardial infarction // Texas Heart Institute J. -2007. - Vol. 34, № 4. - Р. 475-478.Sato Y., Matsumoto N., Matsuo S., Yoda S., Kunimoto S., Saito S. Mid-ventricular hypertrophic obstructive cardiomyopathy presenting with acute myocardial infarction // Texas Heart Institute Journal. 2007;34(4):475-478.Pacheco Claudio C., Quesada O., Pepine C. J. et al. Why names matter for women: MINOCA/INOCA (myocardial infarction/ischemia and no obstructive coronary artery disease) // Clinical Cardiology. - 2018. - Vol. 41, № 2. -Р. 185-193. Doi: 10.1002/clc.22894.Pacheco Claudio C., Quesada O., Pepine C.J., Noel Bairey Merz C. Why names matter for women: MINOCA/IN-OCA (myocardial infarction/ischemia and no obstructive coronary artery disease) // Clinical Cardiology. 2018;41(2):185-193. Doi: 10.1002/clc.22894.Клинические рекомендации «Гипертрофическая кардиомиопатия» / Российское кардиолог. об-во. 2020.Hypertrophic cardiomyopathy: Clinical recommendations / Russian Society of Cardiology. 2020Hamada M. Left Ventricular Thrombus in Hypertrophic Cardiomyopathy // Internal Medicine. - 2019. - Vol. 58, № 4. - Р. 465-467. Doi: 10.2169/internalmedicine.Hamada M. Left Ventricular Thrombus in Hypertrophic Cardiomyopathy // Internal Medicine. 2019;58(4):465-467. Doi: 10.2169/internalmedicine.Raza M., Chalfoun N., Wissam A. et al. Hypertrophic cardiomyopathy with a large apical ventricular aneurysm and mural thrombus // Global Cardiology Science and Practice. -2018. - № 1. - Р. 9. Doi: 10.21542/gcsp.2018.9.Raza M., Chalfoun N., Wissam A., Hashmi H., McNamara R. Hypertrophic cardiomyopathy with a large apical ventricular aneurysm and mural thrombus // Global Cardiology Science and Practice. 2018;(1):9. Doi: 10.21542/gcsp.2018.9.Alfonso F., Frenneaux M. P., McKenna W. J. Clinical sustained uniform ventricular tachycardia in hypertrophic cardiomyopathy: association with left ventricular apical aneurysm // British Heart Journal. - 1989. - Vol. 61, № 2. -Р. 178-181. Doi: 10.1136/hrt.61.2.178.Alfonso F., Frenneaux M. P., McKenna W. J. Clinical sustained uniform ventricular tachycardia in hypertrophic cardiomyopathy: association with left ventricular apical aneurysm // British Heart Journal. 1989;61(2):178-181. Doi: 10.1136/hrt.61.2.178Gao X. J., Kang L. M., Zhang J. et al. Mid-ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm and sustained ventricular tachycardia: a case report and literature review // China M. J. (Engl). - 2011. - Vol. 124, № 11. - Р. 1754-1757.Gao X. J., Kang L. M., Zhang J., Dou K. F., Yuan J. S., Yang Y. J. Mid-ventricular obstructive hypertrophic cardiomyopathy with apical aneurysm and sustained ventricular tachycardia: a case report and literature review // China Medical Journal (Engl). 2011;124(11):1754-1757.Seggewiss H., Faber L. Percutaneous septal ablation for hypertrophic cardiomyopathy and mid-ventricular obstruction // Eur. J. of Echocardiography. - 2000. - № 1. -Р. 277-280. Doi: 10.1053/euje.2000.0032.Seggewiss H., Faber L. Percutaneous septal ablation for hypertrophic cardiomyopathy and mid-ventricular obstruction // European Journal of Echocardiography. 2000; 1:277-280. Doi: 10.1053/euje.2000.0032.Kunkala M. R., Schaff H. V., Nishimura R. A. et al. Transapical approach to myectomy for midventricular obstruction in hypertrophic cardiomyopathy // The Annals of Thoracic Surgery. - 2013. - Vol. 96, № 2. - Р. 564-570. Doi: 10.1016/j.athoracsur.2013.04.073.Kunkala M. R., Schaff H. V., Nishimura R. A., Abel M. D., Sorajja P., Dearani J. A., Ommen S. R. Transapical approach to myectomy for midventricular obstruction in hypertrophic cardiomyopathy // The Annals of Thoracic Surgery. 2013;96(2):564-570. Doi: 10.1016/j.athoracsur.2013.04.073.Said S. M., Schaff H. V., Abel M. D. et al. Transapi-cal approach for apical myectomy and relief of midventricular obstruction in hypertrophic cardiomyopathy // J. of Card Surgery. - 2012. - Vol. 27, № 4. - Р. 443-448. Doi: 10.1111/j.1540-8191.2012.01475.x.Said S. M., Schaff H. V., Abel M. D., Dearani J. A. Transapical approach for apical myectomy and relief of midventricular obstruction in hypertrophic cardiomyopathy // Journal of Card Surgery. 2012;27(4):443-448. Doi: 10.1111/j.1540-8191.2012.01475.x.Yang Y. J., Fan C. M., Yuan J. Q. et al. Effectiveness of alcohol septal ablation versus transaortic extended myectomy in hypertrophic cardiomyopathy with midventricular obstruction // J. of Interventional Cardiology. - 2016. - № 29. -Р. 619-627. Doi: 10.1111/joic.12331Yang Y. J., Fan C. M., Yuan J. Q., Wang S. Y., Song Y. H., Qiao S. B., You S. J., Wang Z. M., Duan F. J., Li Y. S. Effectiveness of alcohol septal ablation versus transaortic extended myectomy in hypertrophic cardiomyopathy with midventricular obstruction // Journal of Interventional Cardiology. 2016;(29):619-627. Doi: 10.1111/joic.12331Nguyen A., Schaff H. V., Nishimura R. A. et al. Early outcomes of repair of left ventricular apical aneurysms in patients with hypertrophic cardiomyopathy // Circulation. -2017. - № 136. - Р. 1979-1981. Doi: 10.1161/CIRCULA-TIONAHA.117.030593.Nguyen A., Schaff H. V., Nishimura R. A., Dearani J. A., Ommen S. R. Early outcomes of repair of left ventricular apical aneurysms in patients with hypertrophic cardiomyopathy // Circulation. 2017;(136):1979-1981. Doi: 10.1161/CIRCULATIONAHA.117.030593.Sato Y., Matsumoto N., Matsuo S. et al. Mid-ventricular obstructive hypertrophic cardiomyopathy associated with an apical aneurysm: evaluation of possible causes of aneurysm formation // Yonsei Med. J. - 2007. - Vol. 48, № 5. - Р. 879-882. Doi: 10.3349/ymj.2007.48.5.879.Sato Y., Matsumoto N., Matsuo S., Yoda S., Tani S., Kasamaki Y., Takayama T., Kunimoto S., Saito S. Mid-ventricular obstructive hypertrophic cardiomyopathy associated with an apical aneurysm: evaluation of possible causes of aneurysm formation // Yonsei Medical Journal. 2007;48(5):879-882. Doi: 10.3349/ymj.2007.48.5.879.Takeda I., Sekine M., Matsushima H. et al. Two cases of cerebral embolism caused by apical thrombi in midventricular obstructive cardiomyopathy // Internal Medicine. -2011. - Vol. 50, № 9. - Р. 1059-1060. Doi: 10.2169/inter-nalmedicine.50.5079Takeda I., Sekine M., Matsushima H., Hosomi N., Nakamura T., Ohtsuki T., Yamawaki T., Matsumoto M. Two cases of cerebral embolism caused by apical thrombi in mid-ventricular obstructive cardiomyopathy // Internal Medicine. 2011;50(9):1059-1060. Doi: 10.2169/internalmedicine.50.5079.Elsheshtawy M. O., Mahmoud A. N., Abdelghany M. et al. Left ventricular aneurysms in hypertrophic cardiomyopathy with midventricular obstruction: A systematic review of literature // Pacing and Clinical Electrophysiology. - 2018. -Vol. 41, № 7. - Р. 854-865. Doi: 10.1111/pace.13380.Elsheshtawy M. O., Mahmoud A. N., Abdelghany M., Suen I. H., Sadiq A., Shani J. Left ventricular aneurysms in hypertrophic cardiomyopathy with midventricular obstruction: A systematic review of literature // Pacing and Clinical Electrophysiology. 2018;41(7):854-865. Doi: 10.1111/pace.13380.Hughes R. K., Knott K. D., Malcolmson J. et al. Apical Hypertrophic Cardiomyopathy: The Variant Less Known // Journal of the American Heart Association. - 2020. - Vol. 9, № 5. - Р. e015294. Doi: 10.1161/JAHA.119.015294.Hughes R. K., Knott K. D., Malcolmson J., Augusto J. B., Mohiddin S. A., Kellman P., Moon J. C., Captur G. Apical Hypertrophic Cardiomyopathy: The Variant Less Known // Journal of the American Heart Association. 2020; 9(5):e015294. Doi: 10.1161/JAHA.119.015294.

The authors declare that there are no conflicts of interest present.