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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">uzspbgmu</journal-id><journal-title-group><journal-title xml:lang="ru">Учёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. Павлова</journal-title><trans-title-group xml:lang="en"><trans-title>The Scientific Notes of the Pavlov University</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1607-4181</issn><issn pub-type="epub">2541-8807</issn><publisher><publisher-name>Academician I.P. Pavlov First St. Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1607-4181-2019-26-1-42-46</article-id><article-id custom-type="elpub" pub-id-type="custom">uzspbgmu-566</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ РАБОТЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL PAPERS</subject></subj-group></article-categories><title-group><article-title>ПАТОГЕНЕТИЧЕСКОЕ ЛЕЧЕНИЕ ФЕРМЕНТАТИВНОГО ПАРАПАНКРЕАТИТА</article-title><trans-title-group xml:lang="en"><trans-title>PATHOGENETIC TREATMENT OF ENZYMATIC PARAPANCREATITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4126-2886</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>Dmitriy V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.</p></bio><bio xml:lang="en"><p>6-8 L’va Tolstogo street, Saint-Petersburg, 197022.</p></bio><email xlink:type="simple">fomka123.91@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корольков</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Korolkov</surname><given-names>Andrey Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">korolkov.a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>Victor P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><email xlink:type="simple">morozov.vp@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ваганов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vaganov</surname><given-names>Alexey A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>St. Petersburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2019</year></pub-date><volume>26</volume><issue>1</issue><fpage>42</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Куликов Д.В., Корольков А.Ю., Морозов В.П., Ваганов А.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Куликов Д.В., Корольков А.Ю., Морозов В.П., Ваганов А.А.</copyright-holder><copyright-holder xml:lang="en">Kulikov D.V., Korolkov A.Y., Morozov V.P., Vaganov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.sci-notes.ru/jour/article/view/566">https://www.sci-notes.ru/jour/article/view/566</self-uri><abstract><sec><title>Введение</title><p>Введение. Наиболее тяжелый компонент острого деструктивного панкреатита (ОДП) – ферментативный пара-панкреатит (ФПП). Методы патогенетического лечения ограничены.</p><p>Цель – оценка эффективности различных методов лечения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В группу 1 включены 86 пациентов с ОДП, ферментативным перитонитом (ФП), ФПП, из них 44 с ФПП выполнена лапароскопическая декомпрессия (ЛД) забрюшинной клетчатки. В группу 2 включены 120 пациентов с ФПП без ФП, 48 – с чрескожным дренированием парапанкреатической клетчатки (ЧДП).</p></sec><sec><title>Результаты</title><p>Результаты. У пациентов с геморрагическим ФПП летальность при ЛД – 16 %, без ЛД – 37 %, при серозном ФПП с ЛД – 15 %, без ЛД – 15 %. У пациентов с ФПП без ФП летальность при ЧПД – 6,2 %, летальность без ЧПД – 8,3 %.</p></sec><sec><title>Выводы</title><p>Выводы. ЛД и ЧПД должны применяться исходя из варианта ФПП.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The most severe component of acute destructive pancreatitis (ADP) is enzymatic parapancreatitis (EPP). Pathogenetic treatment methods are limited.</p><p>The objective was to evaluate the effectiveness of different treatment methods.</p></sec><sec><title>Material and methods</title><p>Material and methods. Group 1 included 86 patients with ADP, enzymatic peritonitis (EP), EPP; 44 patients with EPP of them were performed LD of the retroperitoneal tissue. Group 2 included 120 patients with EPP without EP, 48 – with PPD (percutaneous drainage of parapancreatic tissue).</p></sec><sec><title>Results</title><p>Results. Mortality rate in patients with hemorrhagic EPP with LD was 16 %, without LD – 37 %, in patients with serous EPP with LD – 15 %, without LD –15 %. Mortality rate in patients with EPP without EP and with PPD was 6.2 %, without PPD – 8.3 %</p></sec><sec><title>Conclusion</title><p>Conclusion. LD and PPD should have been applied on the basis of the variant of EPP.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>панкреатит</kwd><kwd>перитонит</kwd><kwd>парапанкреатит</kwd><kwd>лапароскопическая декомпрессия</kwd><kwd>чрескожное дренирование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pancreatitis</kwd><kwd>peritonitis</kwd><kwd>parapancreatitis</kwd><kwd>laparoscopic decompression</kwd><kwd>percutaneous drainage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Деструктивный панкреатит: алгоритм диагностики и лечения (Проект составлен по материалам IX Всеросс. съезда хирургов, состоявшегося 20–22 сент. 2000 г. в г. Волгограде) // Consilium-medicum. – 2001. – Т. 3, № 6.</mixed-citation><mixed-citation xml:lang="en">Destructive pancreatitis: the algorithm for diagnosis and treatment (The project is based on the materials of the IX All-Russian Congress of Physicians, September 20–22, 2000, Volgograd. Consilium-medicum. 2001;3(6). (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Пугаев А. В. Острый панкреатит. – М.: Профиль, 2007. – С. 335.</mixed-citation><mixed-citation xml:lang="en">Pugaev A. V. Acute pancreatitis. Moscow, Profil, 2007:335. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Филимонов М. И., Гельфанд Б. Р., Бурневич С. З. и др. Острый панкреатит: пособие для врачей / под ред. В. С. Савельева. – М.: НЦССХ им. А. Н. Бакулева РАМН, 2000. – С. 3.</mixed-citation><mixed-citation xml:lang="en">Filimonov M. I., Gelfand B. R., Burnevitch S. Z. Acute pancreatitis: a manual for doctors / ed. V. S. Saveliev. Moscow, A. N. Bakulev SCCS of RAMS, 2000:3. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Шелест П. В., Миронов В. И. Диагностика и прогнозирование клинико-морфологических форм острого деструктивного панкреатита // Сибир. мед. журн. – 2007. – № 6. – C. 5–9.</mixed-citation><mixed-citation xml:lang="en">Shelest P. V., Mironov V. I. Diagnostics and prognosis of clinical and morphological forms of acute destructive pancreatitis Siberian Medical Journal. 2007;(6):5–9. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Багненко С. Ф., Рухляда Н. В., Толстой А. Д. Лечение острого панкреатита на ранней стадии заболевания: учеб. пособие / СПбНИИ скорой помощи им. И. И. Джанелидзе. – СПб., 2002. – С. 24.</mixed-citation><mixed-citation xml:lang="en">Bagnenko S. F., Rukhlyada N. V., Tolstoy A. D. i dr. Treatment of acute pancreatitis at an early stage of the disease: Proc. Allowance. SPb. Institute of First Aid to them. I. I. Janelidze. SPb., 2002:24. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дейла М. М., Форомена Дж. К. Руководство по иммунофармакологии. – М.: Медицина, 1998. – С. 332.</mixed-citation><mixed-citation xml:lang="en">Daila M. M. A Guide to Immunopharmacology. Dale, JK Foromena. Moscow, Medicine, 1998:332. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ермолов А. С. Иммунологическая оценка тяжести и прогноза острого панкреатита // Вестн. хир. – 2005. – № 6. – С. 22–28.</mixed-citation><mixed-citation xml:lang="en">Ermolov A. S. Immunological assessment of severity and prognosis of acute pancreatitis. Vestn. khir. 2005;(6):22– 28. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ерюхина И. А. и др. Хирургические инфекции: руководство. – М.; СПб.: Питер, 2003. – С. 864.</mixed-citation><mixed-citation xml:lang="en">Eryukhina I. A. i dr. Surgical infections: leadership. Moscow, SPb., Peter, 2003:864. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Тарасенко В. С., Демин Д. Б., Волков Д. В. Диагностика гнойных осложнений панкреонекроза // Неотлож. и специализир. хирург. помощь: Материалы 1-го конгр. москов. хирургов. – М., 2005. – С. 114–115.</mixed-citation><mixed-citation xml:lang="en">Tarasenko V. S., Demin D. B., Volkov D. V. i dr.Diagnosis of suppurative complications of pancreatonecrosis. Urgent and specialized surgical care: first congress of Moscow surgeons. Moscow, 2005:114–115. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Толстой А. Д., Панов В. П., Краснорогов В. Б. Парапанкреатит (этиология, патогенез, диагностика, лечение). – СПб.: Ясный Свет, 2003. – С. 7.</mixed-citation><mixed-citation xml:lang="en">Tolstoy A. D., Panov V. P., Krasnorogov V. B. Parapancreatitis (etiology, pathogenesis, diagnosis, treatment). SPb., Clear Light, 2003:7. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gotzinger P. Surgical treatment for severe acute pancreatitis: extent and surgical control of necrosis determine outcome. World. J. Surg. 2009;26(4):474–478. Doi: 10.1007/s00268-001-0252-8.</mixed-citation><mixed-citation xml:lang="en">Gotzinger P. Surgical treatment for severe acute pancreatitis: extent and surgical control of necrosis determine outcome. World. J. Surg. 2009;26(4):474–478. DoiI: 10.1007/s00268-001-0252-8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Вашетко Р. В. Морфология местных и общих патологических процессов при остром панкреатите: дис. … д-ра мед. наук. – СПб., 1993. – С. 348.</mixed-citation><mixed-citation xml:lang="en">Vashetko R. V. Morphology of local and general pathological processes in acute pancreatitis: Diss. Dr. med. Sciences. SPb., 1993:348. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
