uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2018-25-3-7-13uzspbgmu-515Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЗАБОЛЕВАНИЕ СПЕКТРА ОПТИКОНЕЙРОМИЕЛИТА: ДИАГНОСТИКА И ЛЕЧЕНИЕ, ОПЫТ КЛИНИЧЕСКИХ НАБЛЮДЕНИЙNEUROMYELITIS OPTICA SPECTRUM DISORDERS: DIAGNOSIS AND TREATMENT, THE EXPERIENCE OF CLINICAL OBSERVATIONShttps://orcid.org/0000-0002-8955-3765ПивеньВ. Д.PivenV. D.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

conter51@yandex.ruКрасновВ. С.KrasnovV. S.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

krasnov_volod@mail.ruНовиковаА. С.NovikovaA. S.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

Vakhoninaanna@mail.ruПивеньФ. М.PivenF. M.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

faina.zernowa@yandex.ruКушнирЯ. Б.KushnirYa. B.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

kushnir.yana2014@yandex.ruТотолянН. А.TotolianN. A.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8.

6-8 L’va Tolstogo street, Saint-Petersburg, Russia, 197022.

ntotolyan@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации.РоссияPavlov University.Russian Federation201830092018253713Copyright © Пивень В.Д., Краснов В.С., Новикова А.С., Пивень Ф.М., Кушнир Я.Б., Тотолян Н.А., 20182018Пивень В.Д., Краснов В.С., Новикова А.С., Пивень Ф.М., Кушнир Я.Б., Тотолян Н.А.Piven V.D., Krasnov V.S., Novikova A.S., Piven F.M., Kushnir Y.B., Totolian N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/515

Заболевание спектра оптиконейромиелита (СОНМ) – совокупность расстройств центральной нервной системы воспалительной и, наиболее вероятно, аутоиммунной природы, с рецидивирующим, инвалидизирующим течением и преимущественным поражением зрительных нервов, спинного мозга и ствола головного мозга. Выделены два варианта заболевания СОНМ: серопозитивный по антителам к аквапорину-4 (AQP4-IgG) и серонегативный, который отмечается в 25 % случаев. Приведены современные представления о данной патологии, представлен собственный опыт клинических наблюдений пациентов. 

Neuromyelitis optica spectrum disorder (NMOSD) is an aggregate of inflammatory and autoimmune disorders of the central nervous system characterized by recurrent, disabling clinical course and damages predominantly targeting optic nerves, brain stem and spinal cord. NMOSD is stratified into two types: seropositive for aquaporin-4 antibodies (AQP4-IgG) and seronegative, which is reported in 25 % of cases. This article presents modern conceptualizations of NMOSD and describes authors’ own experience of clinical observation of patients.

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The authors declare that there are no conflicts of interest present.