uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2018-25-2-19-31uzspbgmu-511Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESОСОБЕННОСТИ ВЛИЯНИЯ РАЗЛИЧНЫХ ФОРМ ВИТАМИНА D НА КОСТНО-СУСТАВНУЮ СИСТЕМУFEATURES OF THE EFFECT OF VARIOUS FORMS OF VITAMIN D ON THE BONE AND JOINT SYSTEMДулаевА. К.DulaevA. K.

Санкт-Петербург

Saint-Petersburg

ЦедА. Н.TsedA. N.

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Saint-Petersburg

tsed@mail.ruФильченкоИ. А.FilchenkoI. A.

Санкт-Петербург

Saint-Petersburg

МуштинН. Е.MushtinN. E.

Санкт-Петербург

Saint-Petersburg

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2018300620182521931Copyright © Дулаев А.К., Цед А.Н., Фильченко И.А., Муштин Н.Е., 20182018Дулаев А.К., Цед А.Н., Фильченко И.А., Муштин Н.Е.Dulaev A.K., Tsed A.N., Filchenko I.A., Mushtin N.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/511

Витамин D принимает участие в метаболизме костной ткани, регулируя процессы минерализации и ремоделирования. Имеются многочисленные сведения об использовании витамина D у больных травматолого-ортопедического профиля, однако мнения о способе введения, дозах, эффективности весьма разнятся и требуют более углубленного изучения.

Цель работы состояла в проведении обзора и анализа актуальных клинических и экспериментальных исследований, связанных с изучением влияния метаболитов витамина D при эндопротезировании крупных суставов, среди доступных медицинских источников баз данных PubMed, Cohraine, e-Library.

Результаты большинства исследований местного и системного использования метаболитов витамина D позволяют сделать вывод о благотворном влиянии данных соединений на регенерацию костной ткани в травматологии и ортопедии. Тем не менее для однозначного определения возможностей клинического применения обозначенных подходов необходимы дальнейшие исследования.

Мы предполагаем, что в перспективных работах следует учитывать следующие факторы: оценка долгосрочного эффекта и использование стандартизованных доз, изучение новых производных витамина D, синергизма в комбинациях препаратов витамина D, фармакокинетики препаратов витамина D и полиморфизмов генов, ассоциированных с витамином D, и генов, влияющих на жизнедеятельность костной ткани, а также оценка влияния сопутствующих заболеваний и системных патологических процессов на метаболизм витамина D и восстановление костной ткани. Также мы определяем одновременную коррекцию уровней витамина D как важную составляющую компенсации костных нарушений у травматологических и ортопедических пациентов. 

Vitamin D takes part into the metabolism of the bone tissue, regulating the processes of mineralization and remodeling. There are a lot of data on uses of using of vitamin D in patients of trauma and orthopedic profile, but opinions about the method of taking, dosage, effectiveness differ greatly and requires more in-depth research.

The objective of this study was to review and analyze of actual clinical and experimental researches related to the influence of metabolites of vitamin D in the endoprosthesis of large joints, among the available sources of medical database of PubMed, Cohraine, e-Library.

The results of most studies of local and systemic use of metabolites of vitamin D led to the conclusion about the beneficial effects of these compounds on bone regeneration in traumatology and orthopedics. However, further researches are required to clearly identify the clinical application of these approaches.

We supposed that the following factors considered for long-term work: assessment of long-term effect and usage of standardized doses, learning new derivatives of vitamin D, synergy in the combinations of vitamin D preparations, pharmacokinetics of vitamin D preparations and polymorphisms of genes associated with vitamin D, genes influencing the life activity of bone and assessment of the effect of concomitant disease, systemic pathological processes on related of vitamin D metabolism, and bone restoration. We are also define the simultaneous corrections of vitamin D levels as an important component of the compensation of bone disorders in trauma and orthopedic patients.

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The authors declare that there are no conflicts of interest present.