uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2014-21-1-6-10uzspbgmu-5Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСОВРЕМЕННЫЕ ПОДХОДЫ К ТЕРАПИИ ПРИ БОЛЕЗНИ АЛЬЦГЕЙМЕРА: ОТ АМИЛОИДА К ПОИСКУ НОВЫХ МИШЕНЕЙModern approach in the therapy of Alzheimer's diseaseРодинД. И.RodinD. I.noemail@neicon.ruШварцманА. Л.SchvarzmanA. L.noemail@neicon.ruСаранцеваС. В.SaranzevaS. V.noemail@neicon.ruНИЦ «Курчатовский институт» Петербургского института ядерной физики имени Б.П. Константинова; Институт экспериментальной медициныRussian Federation201430032014211610Copyright © Родин Д.И., Шварцман А.Л., Саранцева С.В., 20142014Родин Д.И., Шварцман А.Л., Саранцева С.В.Rodin D.I., Schvarzman A.L., Saranzeva S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/5

Болезнь Альцгеймера - нейродегенеративное заболевание, одним из наиболее важных факторов риска развития которого является возраст. Показано, что с увеличением продолжительности жизни человека в развитых странах, а также с увеличением доли пожилых людей в популяции БА стала самой распространенной формой среди деменций разного типа. Несмотря на огромный объем накопленных за последнее время данных, этиология заболевания остается неясной. В данный момент не существует эффективных фармакологических препаратов, способных предотвратить или, по крайней мере, замедлить развитие болезни, которая обычно кончается смертельным исходом в течение 5-9 лет после постановки диагноза. В обзоре представлены наиболее перспективные разработки лекарственных средств, находящиеся на стадии клинических испытаний.

Alzheimer's disease is a well-known neurodegenerative disorder. One of its main risk factors is age. Due to a worldwide increase of human longevity Alzheimer's disease became the most common form of dementia. The disease has been studied in different countries for many decades but still its etiology remains unclear. By now there is no cure for Alzheimer's, moreover there are no that can at least slow down the disease progression. In this review we made an attempt to summarize all current studies of the most advanced drugs for Alzheimer's.

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The authors declare that there are no conflicts of interest present.