uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2017-24-3-40-47uzspbgmu-443Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSКЛИНИКО-МОРФОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ РОЛИ ФАКТОРА ТРАНСКРИПЦИИ NEUROD1 В РАЗЛИЧНЫХ ТИПАХ АДЕНОМ ГИПОФИЗАCLINICAL AND MORPHOLOGICAL RESEARCH INTO THE ROLE OF THE TRANSCRIPTION FACTOR NEUROD1 IN VARIOUS TYPES OF PITUITARY ADENOMASРаспоповаО. М.RaspopovaO. M.

Ольга Михайловна Распопова - младший научный сотрудник, аспират

olgarasp@yandex.ruhttps://orcid.org/0000-0003-0735-7822МитрофановаЛ. Б.MitrofanovaL. B.

Любовь Борисовна Митрофанова - зав. НИЛ патоморфологии, доктор медицинских наук.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197143

Lubov B. Мitrofanova.

Akkuratova street, 2, St. Petersburg, 197143

lubamitr@yandex.ruГальковскийБ. Э.GalkovskyB. E.

Борис Эдуардович Гальковский - ординатор 2 года по патологческой анатомии

mrc4se@gmail.comЦойУ. А.TsoyU. A.

Ульяна Александровна Цой - врач-эндокринолог, кандидат медицинских наук, докторант

utsoi@mail.ruГриневаЕ. Н.GrinevaU. N.

Елена Николаевна Гринева - доктор медицинских наук, профессор, врач-эндокринолог, директор Института эндокринологии

grineva_e@mail.ruПальцевА. А.PalcevA. A.

Артем Александрович Пальцев - зав. отделением нейрохирургии, кандидат медицинских наук

palcev_aa@almazovcentre.ruРодичкинаВ. Р.RodichkinaV. R.

Валерия Руслановна Родичкина – младший научный сотрудник лаборатории клеточной биологии

rolerus@mail.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В.А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное учреждение Научно-исследовательский институт акушерства, гинекологоии и репродуктологии имени Д.О. ОттаРоссияOtt Research Institute of Obstetrics and GynecologyRussian Federation2017300920172434047Copyright © Распопова О.М., Митрофанова Л.Б., Гальковский Б.Э., Цой У.А., Гринева Е.Н., Пальцев А.А., Родичкина В.Р., 20172017Распопова О.М., Митрофанова Л.Б., Гальковский Б.Э., Цой У.А., Гринева Е.Н., Пальцев А.А., Родичкина В.Р.Raspopova O.M., Mitrofanova L.B., Galkovsky B.E., Tsoy U.A., Grineva U.N., Palcev A.A., Rodichkina V.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/443

Сведения о роли факторов транскрипции в патогенезе аденом гипофиза крайне противоречивы.

Целью исследования явилось изучение роли фактора транскрипции NeuroD1 в различных типах аденом гипофиза.

Материал и методы

Материал и методы. Выполнено сравнительное клинико-морфологическое исследование с иммуногистохимическим анализом и конфокальной микроскопией экспрессии фактора транскрипции NeuroD1 6 гормонов аденогипофиза и Ki-67 в 40 различных аденомах гипофиза и 9 нормальных аденогипофизах.

Результаты исследования

Результаты исследования. NeuroD1 экспрессировался во всех случаях и типах аденом, уровень его экспрессии в 40 аденомах достоверно отличался от такового в нормальном гипофизе (р=0,006), при этом NeuroD1 во всех опухолях был выше, чем в норме.

Заключение

Заключение. NeuroD1 играет одну из ключевых ролей в патогенезе аденом гипофиза вне зависимости от их гормонального статуса.

The role of transcription factors in the pathogenesis of pituitary adenomas is extremely controversial.

The aim of the study was to investigate the role of the transcription factor Neuro D1 in various types of pituitary adenomas.

Materials and methods

Materials and methods. A comparative clinico-morphological study was carried out with immunohistochemical analysis and confocal microscopy of the expression of the transcription factor NeuroD1, six adenohypophysis hormones and Ki-67 in 40 pituitary adenomas and 9 normal pituitary glands.

Results

Results. NeuroD1 was expressed in all cases and types of adenomas. The expression level of the transcription factor in adenomas was significantly different from that in the normal pituitary gland (p = 0.006). The average number of cells with expression of NeuroD1 in all tumors was higher than in the normal pituitary gland.

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The authors declare that there are no conflicts of interest present.