uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical Universityuzspbgmu-218Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSВЛИЯНИЕ НИКОТИНОВОЙ КИСЛОТЫ НА ВЫЖИВАЕМОСТЬ И НЕЙРОДЕГЕНЕРАЦИЮ В МОЗГЕ ТРАНСГЕННЫХ DROSOPHILA MELANOGASTER С ГИПЕРЭКСПРЕССИЕЙ ГЕНА АРР ЧЕЛОВЕКАEffect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP geneБольшаковаО. И.BolshakovaO. I.РодинД. И.RodinD. I.ТимошенкоС. И.TimoshenkoS. I.ЛатыповаЕ. М.LatypovaE. M.СаранцеваС. В.SarantsevaS. V.СанктПетербургский институт ядерной физики имени Б. П. Констан
тинова, г. ГатчинаRussian Federation2013300920132031417Copyright © Большакова О.И., Родин Д.И., Тимошенко С.И., Латыпова Е.М., Саранцева С.В., 20132013Большакова О.И., Родин Д.И., Тимошенко С.И., Латыпова Е.М., Саранцева С.В.Bolshakova O.I., Rodin D.I., Timoshenko S.I., Latypova E.M., Sarantseva S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/218НИКОТИНОВАЯ КИСЛОТАДРОЗОФИЛАБОЛЕЗНЬ АЛЬЦГЕЙМЕРАNICOTINIC ACIDALZHEIMER''S DISEASEDROSOPHILA MELANOGASTERReferencesGray S.G., Dangond F. Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis//Epigenetics. -2006. № 1 (2). -Р. 67 -75.Gray S.G., Dangond F. Rationale for the use of histone deacetylase inhibitors as a dual therapeutic modality in multiple sclerosis//Epigenetics. -2006. № 1 (2). -Р. 67 -75.Haass C., Schlossmacher M.G., Hung A.Y. et al. Amyloid beta-peptide is produced by cultured cells during normal metabolism//Nature. -1992. -№ 359. -Р. 322-325.Haass C., Schlossmacher M.G., Hung A.Y. et al. Amyloid beta-peptide is produced by cultured cells during normal metabolism//Nature. -1992. -№ 359. -Р. 322-325.Hoane M.R., Tan A.A., Pierce J.L. et al. Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat//J. Neurotrauma. -2006. -№ 23 (10). -Р. 1535-1548.Hoane M.R., Tan A.A., Pierce J.L. et al. Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat//J. Neurotrauma. -2006. -№ 23 (10). -Р. 1535-1548.Jeibmann A., Paulus W. Drosophila melanogaster as a Model Organism of Brain Diseases.//Int. J. Mol. Sci. -2009. -№ 10. -Р. 407-440.Jeibmann A., Paulus W. Drosophila melanogaster as a Model Organism of Brain Diseases.//Int. J. Mol. Sci. -2009. -№ 10. -Р. 407-440.Jia H., Li X., Gao H. et al. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease//J. Neurosci. Res. -2008. -№ 86 (9). -Р. 2083-2090.Jia H., Li X., Gao H. et al. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease//J. Neurosci. Res. -2008. -№ 86 (9). -Р. 2083-2090.Knip M., Douek I.F., Moore W.P. et al. European Nicotinamide Diabetes Intervention Trial Group. Safety of high-dose nicotinamide: a review//Diabetologia. -2000. -№ 43 (11). -Р. 1337-45.Knip M., Douek I.F., Moore W.P. et al. European Nicotinamide Diabetes Intervention Trial Group. Safety of high-dose nicotinamide: a review//Diabetologia. -2000. -№ 43 (11). -Р. 1337-45.Liu D., Gharavi R., Pitta M. et al. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons//Neuromolecular Med. -2009. -№ 11 (1). -Р. 28-42.Liu D., Gharavi R., Pitta M. et al. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons//Neuromolecular Med. -2009. -№ 11 (1). -Р. 28-42.MacKay D., Hathcock J., Guarneri E. Niacin: chemical forms, bioavailability, and health effects//Nutr. Rev. -2012. -№ 70 (6). -Р. 357-366.MacKay D., Hathcock J., Guarneri E. Niacin: chemical forms, bioavailability, and health effects//Nutr. Rev. -2012. -№ 70 (6). -Р. 357-366.Morris M.C., Evans D.A., Bienias J.L. et al. Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline//J. Neurol. Neurosurg. Psychiatry. -2004. -№ 75 (8). -Р. 1093-1099.Morris M.C., Evans D.A., Bienias J.L. et al. Dietary niacin and the risk of incident Alzheimer's disease and of cognitive decline//J. Neurol. Neurosurg. Psychiatry. -2004. -№ 75 (8). -Р. 1093-1099.Morris M.C., Schneider J.A., Tangney C.C. Thoughts on B-vitamins and dementia//J. Alzheimers. Dis. -2006. -№ 9 (4). -Р. 429-433.Morris M.C., Schneider J.A., Tangney C.C. Thoughts on B-vitamins and dementia//J. Alzheimers. Dis. -2006. -№ 9 (4). -Р. 429-433.Pandey U.B., Nichols C.D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery//Pharmacol. Rev. -2011. -№ 63 (2). -Р. 411-436.Pandey U.B., Nichols C.D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery//Pharmacol. Rev. -2011. -№ 63 (2). -Р. 411-436.Ricobaraza A., Cuadrado-Tejedor M., Perez-Mediavilla A. et al. Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model//Neuropsychopharmacology. -2009. -№ 34. -P. 1721 -1732.Ricobaraza A., Cuadrado-Tejedor M., Perez-Mediavilla A. et al. Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model//Neuropsychopharmacology. -2009. -№ 34. -P. 1721 -1732.Sarantseva S., Timoshenko S., Bolshakova O. et al. Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease//PLoS One. -2009. -№ 4 (12). -P. 8191.Sarantseva S., Timoshenko S., Bolshakova O. et al. Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease//PLoS One. -2009. -№ 4 (12). -P. 8191.
The authors declare that there are no conflicts of interest present.