uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2014-21-1-57-59uzspbgmu-20Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSВЛИЯНИЕ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНА АПОЛИПОПРОТЕИНА А-I НА ЛИПИДНЫЙ СПЕКТР ПЛАЗМЫ КРОВИ В ПОПУЛЯЦИИ САНКТ-ПЕТЕРБУРГАAssociation of polymorphisms in apolipoprotein A-I gene with plasma lipid profile in population of Saint-PetersburgМирошниковаВ. В.MiroshnikovaV. V.noemail@neicon.ruПантелееваА. А.PanteleevaA. A.noemail@neicon.ruПчелинаС. Н.PchelinaS. N.noemail@neicon.ruШварцманА. Л.SchwarzmanA. L.noemail@neicon.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Петербургский институт ядерной физики имени Б.П. КонстантиноваРоссия2014300320142115759Copyright © Мирошникова В.В., Пантелеева А.А., Пчелина С.Н., Шварцман А.Л., 20142014Мирошникова В.В., Пантелеева А.А., Пчелина С.Н., Шварцман А.Л.Miroshnikova V.V., Panteleeva A.A., Pchelina S.N., Schwarzman A.L.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/20

Аполипопротеин А-I является основным структурным белком антиатерогенных липопротеинов высокой плотности (ЛПВП). Целью исследования явился анализ корреляции полиморфных вариантов (-75) G/A и 83C/T гена APOA1 с уровнем липидов плазмы крови в популяции Санкт-Петербурга. Было установлено, что аллель T83 гена APOA1, ассоциированный со снижением риска развития атеросклероза у жителей Санкт-Петербурга, характеризуется более высоким уровнем холестерина в составе ЛПВП (p<0,02) и более низким значением коэффициента атерогенности (p<0,02). Таким образом, показано, что антиатерогенная роль аллеля T83 гена APOA1 связана с влиянием вариантов 83C/T гена APOA1 на липидный спектр плазмы крови.

Apolipoprotein A-I is a key structure protein of antiatherogenic high density lipoproteins (HDL). The aim of the study was to investigate the relationship between (-75)G/A and 83C/T polymorphic variants of apolipoprotein A-I gene (APOA1) and the plasma lipid profile in the population of Saint-Petersburg. Allele T83 of APOA1 gene was found to be associated with the reduced risk of atherosclerosis development among Saint-Petersburg inhabitants. The study demonstrates that allele T83 of APOA1 gene is associated with higher plasma HDL cholesterol levels (p<0.02) and with reduced atherogenic ratio (p<0.02) in the population of Saint-Petersburg. Antiatherogenic role of allele T83 is related to the influence of 83C/T polymorphic variants of APOA1 gene on the plasma lipid profile.

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The authors declare that there are no conflicts of interest present.