uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2016-23-1-47-50uzspbgmu-179Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSСостояние глазной поверхности при псевдоэксфолиативном синдромеOcular surface condition in patients with pseudoexfoliative syndromeПотемкинВ. В.PotemkinV. V.АгееваЕ. В.AgeevaE. V.Первый Санкт-Петербургского государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov First State Medical University of St. PetersburgRussian Federation2016300320162314750Copyright © Потемкин В.В., Агеева Е.В., 20162016Потемкин В.В., Агеева Е.В.Potemkin V.V., Ageeva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/179

Проведена оценка состояния глазной поверхности в группах обследованных с псевдоэксфолиативным синдромом и без него. В группе с псевдоэксфолиативным синдромом отмечается статистически значимое снижение слезопродукции (тест Ширмера II), времени разрыва слезной пленки и выраженное повреждение поверхности конъюнктивы (прокрашивание флюоресцеином). По данным опросника, отражающего индекс повреждения глазной поверхности, у пациентов с псевдоэксфолиативным синдромом более выражены клинические проявления синдрома сухого глаза.

In the article the ocular surface was assessed in groups of patients with and without pseudoexfoliative syndrome. Tear secretion (Schirmer test II) and break up time reduction and significant damage of conjunctiva surface (staining with fluorescein) weremarked in group of patients with pseudoexfoliative syndrome. According to questionnaire which reflects index of damage of ocular surface, clinical implications of ocular surface disease was higher in group of patients with pseudoexfoliative syndrome.

псевдоэксфолиативный синдромсухой глазглазная поверхностьpseudoexfoliativesyndromedry eyeocular surfaceReferencesAssessing the severity of conjunctivochalasis in a senile population: a communitybased epidemiology study in Shanghai, China / X. Zhang, Q. Li., H. Zouet al.//BMC Public Health. – 2011. – P.11–198.Assessing the severity of conjunctivochalasis in a senile population: a communitybased epidemiology study in Shanghai, China / X. Zhang, Q. Li., H. Zouet al.//BMC Public Health. – 2011. – P.11–198.Boldt J. Lidparallel conjunctival folds (LIPCOFs) are also a reliable indication of the dry eye condition in patients with diabetes, regardless of the regulation of the diabetes / J. Boldt, H. Hoh// Contactologia.–2000. – Vol. 22. – P. 68–73.Boldt J. Lidparallel conjunctival folds (LIPCOFs) are also a reliable indication of the dry eye condition in patients with diabetes, regardless of the regulation of the diabetes / J. Boldt, H. Hoh// Contactologia.–2000. – Vol. 22. – P. 68–73.Central corneal mechanical sensitivity in pseudoexfoliation syndrome / E.T. Detorakis, S. Koukoula, F. Chrisohoou et al. //Cornea. – 2005. – Vol. 24. – P.688–691.Central corneal mechanical sensitivity in pseudoexfoliation syndrome / E.T. Detorakis, S. Koukoula, F. Chrisohoou et al. //Cornea. – 2005. – Vol. 24. – P.688–691.Conjunctival impression cytology in pseudoexfoliative glaucoma and pseudoexfoliation syndrome/ H. Erdogan, D. S. Arici, M. I. Toker et al.// Clin. Experim. Ophthalmol. – 2006. – Vol. 34.– P. 108–113.Conjunctival impression cytology in pseudoexfoliative glaucoma and pseudoexfoliation syndrome/ H. Erdogan, D. S. Arici, M. I. Toker et al.// Clin. Experim. Ophthalmol. – 2006. – Vol. 34.– P. 108–113.Conway R.M. Pseudoexfoliation syndrome: pathologic manifestations of relevance to intraocular surgery / R.M. Conway, U. SchlotzerSchrehardt, M. Kuchle, G.O. Naumann// Clin. Experiment. Ophthalmol.– 2004. – Vol. 32.– P. 199–210.Conway R.M. Pseudoexfoliation syndrome: pathologic manifestations of relevance to intraocular surgery / R.M. Conway, U. SchlotzerSchrehardt, M. Kuchle, G.O. Naumann// Clin. Experiment. Ophthalmol.– 2004. – Vol. 32.– P. 199–210.DEWS. Methodologies to diagnose and monitor dry eye disease. Report of the Diagnostic Methodology Subcomittee of the International Dry Eye Workshop // Ocul. Surf.– 2007. – Vol. 5. – P. 108–152.DEWS. Methodologies to diagnose and monitor dry eye disease. Report of the Diagnostic Methodology Subcomittee of the International Dry Eye Workshop // Ocul. Surf.– 2007. – Vol. 5. – P. 108–152.Evaluation of subjective assessments and objective diagnostic tests fordiagnosing tearfilm disorders known to cause ocular irritation / S. C. Pflugfelder, S.C. Tseng, O. Sanabria et al.//Cornea. – 1998.– Vol. 17. – P. 38–56.Evaluation of subjective assessments and objective diagnostic tests fordiagnosing tearfilm disorders known to cause ocular irritation / S. C. Pflugfelder, S.C. Tseng, O. Sanabria et al.//Cornea. – 1998.– Vol. 17. – P. 38–56.Hoh H. Lidparallel conjunctival folds (LIPCOF): a definite diagnostic sign of dry eye / H. Hoh, F. Schirra, C. Kienecker, K.W. Ruprecht // Ophthalmologe. – 1995. – P. 802–808.Hoh H. Lidparallel conjunctival folds (LIPCOF): a definite diagnostic sign of dry eye / H. Hoh, F. Schirra, C. Kienecker, K.W. Ruprecht // Ophthalmologe. – 1995. – P. 802–808.8Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome/G.G. Koliakos, A.G. Konstas, U. Schlo?tzerSchrehardt et al.//Br. J. Ophthalmol. – 2003. – Vol. 87. – P. 353–356.8Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome/G.G. Koliakos, A.G. Konstas, U. Schlo?tzerSchrehardt et al.//Br. J. Ophthalmol. – 2003. – Vol. 87. – P. 353–356.Kocabeyoрlu S. Evaluation of the Ocular Surface Parameters in Pseudoexfoliation Syndrome and Conjunctivochalasis, Hacettepe University School of Medicine, Department of Ophthalmology/ S. Kocabeyoрlu, M. Эrkec, M. Orhan, M. Mocan.– 2012.Kocabeyoрlu S. Evaluation of the Ocular Surface Parameters in Pseudoexfoliation Syndrome and Conjunctivochalasis, Hacettepe University School of Medicine, Department of Ophthalmology/ S. Kocabeyoрlu, M. Эrkec, M. Orhan, M. Mocan.– 2012.Meller D., TsengS. C. G. Conjunctivochalasis: Literature review and possible pathophysiology// Surv. Ophthalmol. – 1998. – Vol. 43.– P. 225–232.Meller D., TsengS. C. G. Conjunctivochalasis: Literature review and possible pathophysiology// Surv. Ophthalmol. – 1998. – Vol. 43.– P. 225–232.Moreno J. Pseudoexfoliation syndrome: clinical factors related to capsular rupture in cataract surgery / J. Moreno, S. Duch, J. Lajara // Act. Ophthalmol. – 1993. – Vol. 71.– P.181–184.Moreno J. Pseudoexfoliation syndrome: clinical factors related to capsular rupture in cataract surgery / J. Moreno, S. Duch, J. Lajara // Act. Ophthalmol. – 1993. – Vol. 71.– P.181–184.Murube J. Characteristics and etiology of conjunctivochalasis: historical perspective /J.Murube // Ocul.Surf.–2005. – Vol. 3.– P.7–12.Murube J. Characteristics and etiology of conjunctivochalasis: historical perspective /J.Murube // Ocul.Surf.–2005. – Vol. 3.– P.7–12.Prooxidantantioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma /G. G. Koliakos, C.D. Befani, D. Mikropoulos et al. // Graefes Arch. Clin. Exp. Ophthalmol. – 2008. – Vol. 246. – P.1477–1483.Prooxidantantioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma /G. G. Koliakos, C.D. Befani, D. Mikropoulos et al. // Graefes Arch. Clin. Exp. Ophthalmol. – 2008. – Vol. 246. – P.1477–1483.Ritch R. Exfoliation syndromethe most common identifiable cause of openangle glaucoma // J. Glaucoma. – 1994. – Vol. 3. – P. 176–177.Ritch R. Exfoliation syndromethe most common identifiable cause of openangle glaucoma // J. Glaucoma. – 1994. – Vol. 3. – P. 176–177.Ritch R., SchlotzerSchrehardt U.Exfoliation syndrome //Survey of Ophthalmology. –2001.– Vol. 45. – P. 265–313.Ritch R., SchlotzerSchrehardt U.Exfoliation syndrome //Survey of Ophthalmology. –2001.– Vol. 45. – P. 265–313.Role of Lysyl oxidaselike 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma/ S. Micheal,M. I. Khan, F. Akhtar et al. // Mol. Vis. – 2012.– Vol. 18.– P. 1040–1044.Role of Lysyl oxidaselike 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma/ S. Micheal,M. I. Khan, F. Akhtar et al. // Mol. Vis. – 2012.– Vol. 18.– P. 1040–1044.SchlotzerSchrehardt U., Naumann G. O.Ocular and systemic pseudoexfoliation syndrome// Am. J.Ophthalmol. –2006. – Vol. 141. – P. 921–937.SchlotzerSchrehardt U., Naumann G. O.Ocular and systemic pseudoexfoliation syndrome// Am. J.Ophthalmol. –2006. – Vol. 141. – P. 921–937.Takai Y., Tanito M., OhiraA.Multiplex cytokine analysis of aqueous humor in eyes with primary openangle glaucoma, exfoliation glaucoma, and cataract // Invest. Ophthalmol. – 2012. – P. 241–247.Takai Y., Tanito M., OhiraA.Multiplex cytokine analysis of aqueous humor in eyes with primary openangle glaucoma, exfoliation glaucoma, and cataract // Invest. Ophthalmol. – 2012. – P. 241–247.Walt J.G.., Rowe M. M., Stern K. L. Evaluating the functional impact of dry eye: the ocular surface disease index (abstract)// Drug. Inf. J. – 1997. – № 31. – Р. 1436.Walt J.G.., Rowe M. M., Stern K. L. Evaluating the functional impact of dry eye: the ocular surface disease index (abstract)// Drug. Inf. J. – 1997. – № 31. – Р. 1436.Zonular dialysis during extracapsular cataract extraction iin pseudoexfoliation syndrome/ G.L. Skuta, R.K. Parrish, E. Hod-app et al. // Arch. Ophthalmol. – 1987. – Vol. 105. –№ 63. – Р. 632–634.Zonular dialysis during extracapsular cataract extraction iin pseudoexfoliation syndrome/ G.L. Skuta, R.K. Parrish, E. Hod-app et al. // Arch. Ophthalmol. – 1987. – Vol. 105. –№ 63. – Р. 632–634.

The authors declare that there are no conflicts of interest present.