uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2015-22-4-76-80uzspbgmu-160Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSИНТЕРПРЕТАЦИЯ АМИНОКИСЛОТНОГО ПРОФИЛЯ ПЛАЗМЫ КРОВИ С ИСПОЛЬЗОВАНИЕМ ПОЛИМАРКЕРНОГО ПОДХОДАInterpretation of plasma amino acid profile using multiple marker approachСубботинаТ. Ф.SubbotinaT. F.noemail@neicon.ruЖлобаА. А.ZhlobaA. A.noemail@neicon.ruАлексеевскаяЕ. С.AlexeevskayaE. S.noemail@neicon.ruБируляИ. В.BirulyaI. V.noemail@neicon.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаRussian Federation2015301220152247680Copyright © Субботина Т.Ф., Жлоба А.А., Алексеевская Е.С., Бируля И.В., 20152015Субботина Т.Ф., Жлоба А.А., Алексеевская Е.С., Бируля И.В.Subbotina T.F., Zhloba A.A., Alexeevskaya E.S., Birulya I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/160

При анализе аминокислотного профиля плазмы крови группы пациентов с патологией выходного тракта левого желудочка (n=151) выявлено повышение уровней серина, аланина, аргинина и лизина, что может быть связано с развитием недостаточности кровообращения и митохондриальной дисфункции. Дифференцирование интервала референтных значений помогает в оценке индивидуальных аминокислотных профилей.

In the analysis of plasma amino acid profile in a group of patients with left ventricular outflow tract pathology (n = 151) increased levels of serine, alanine, arginine, and lysine has been found. These metabolic shifts can be linked with the development of circulatory deficiency and mitochondrial dysfunction. The differentiation of the reference values intervals helps in the assessment of individual amino acid profiles.

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The authors declare that there are no conflicts of interest present.