uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2015-22-3-20-24uzspbgmu-128Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESВОЗМОЖНОСТИ ПРИМЕНЕНИЯ МЕЛАТОНИНА В ЛЕЧЕНИИ БОЛЬНЫХ С ХИРУРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИPossible applications of melatonin in the treatment of patients with surgical diseasesСедовВ. М.SedovV. M.noemail@neicon.ruПлиссМ. М.PlissM. M.noemail@neicon.ruФишманМ. Б.FishmanM. B.noemail@neicon.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; НИИ хирургии и неотложной медициныRussian Federation2015300920152232024Copyright © Седов В.М., Плисс М.М., Фишман М.Б., 20152015Седов В.М., Плисс М.М., Фишман М.Б.Sedov V.M., Pliss M.M., Fishman M.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/128

Со времени начала широкого внедрения малоинвазивных лапароскопических технологий в абдоминальной хирургии возник вопрос - в чем заключаются их физиологические отличия от операций c лапаротомным доступом. Исследование таких различий, механизмов и их коррекции позволяет приблизить результаты операций с открытым доступом к лапароскопическим. Однако возможности эффективного системного воздействия, позволяющего коррегировать реакцию организма на хирургические манипуляции, остаются неизученными. На сегодняшний день использование мелатонина в хирургической практике базируется на его функциях как нейромедиатора, способного потенциировать некоторые естественные защитные реакции организма. В работе анализируются эффекты мелатонина, позволяющие использовать его как биологический адаптогенный регулятор, который в целом выполняет роль триггера в запуске разнообразных, в том числе репаратив-ных процессов в организме. Использование адаптационных механизмов, инициируемых мелатонином в ответ на операционную травму и опухолевые процессы, может быть с успехом применено для улучшения результатов оперативного лечения пациентов с хирургическими заболеваниями оперируемых как открытым так и лапароскопическим доступом.

Since the widespread introduction of minimally invasive laparoscopic techniques in abdominal surgery there was a question - what are their physiological differences from operations withapproach by laparotomy. The study of these differences, mechanisms and their correction allows you to bring the results of operations with open approach to the laparoscopic. However, the possibility of an effective systemic exposure, allowing adapting body reaction to surgical procedures remains unresolved. To date, the use of melatonin in surgical practice is based on its functions as a neurotransmitter that can potentiate some natural protective reaction of the body. The paper analyzes the effects of melatonin, you can use as a biological adaptogenic control which generally acts as a trigger to launch a diver-seprocesses, including reparative ones in the body. The use of adaptive mechanisms initiated by melatonin in response to surgical trauma and tumor processes can be successfully applied to improve the results of surgical treatment of patients with surgical diseases operated as open and laparoscopic access.

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The authors declare that there are no conflicts of interest present.