uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2026-33-2-23-30uzspbgmu-1258Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESОбзор возможностей аутологичной богатой тромбоцитами плазмы (PRP) в лечении хронических и длительно незаживающих ранOverview of the potential of autologous platelet-rich plasma (PRP) in the treatment of chronic and long-healing woundshttps://orcid.org/0000-0002-9242-9941ХубулаваГ. Г.КhubulavaG. G.

Хубулава Геннадий Григорьевич, доктор медицинских наук, профессор, академик РАН, зав. кафедрой хирургии факультетской с курсом лапароскопической хирургии и сердечно-сосудистой хирургии с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Khubulava Gennadiy G., Dr. of Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head of the Department of Faculty Surgery with the course of Laparoscopic Surgery and Cardiovascular Surgery with the Clinic

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

ggkh07@rambler.ruhttps://orcid.org/0009-0003-2764-165XСеребрянскаяЕ. И.SerebrianskaiaE. I.

Серебрянская Екатерина Игоревна, аспирант кафедры хирургии факультетской с курсом лапароскопической хирургии и сердечно-сосудистой хирургии с клиникой; врач отделения пластической хирургии ЗАО МЕДИ

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Serebryanskaya Ekaterina I., Postgraduate Student of the Department of Faculty Surgery with the course of Laparoscopic Surgery and Cardiovascular Surgery with the Clinic

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

Serebryanskaya.doc@gmail.comhttps://orcid.org/0009-0006-9985-0823МальянцА. А.MalyantsA. A.

Мальянц Анастасия Александровна, студент 5 курса лечебного факультета

191015, Санкт-Петербург, ул. Кирочная, д. 41 

Malyants Anastasia A., 5th-year Student of the Faculty of Medicine

41, Kirochnaya str., Saint Petersburg, 191015 

Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov UniversityRussian FederationСеверо-Западный государственный медицинский университет имени И. И. МечниковаРоссияNorth-Western State Medical University named after I.I. MechnikovRussian Federation2026091020263322330Copyright © Хубулава Г.Г., Серебрянская Е.И., Мальянц А.А., 20262026Хубулава Г.Г., Серебрянская Е.И., Мальянц А.А.Кhubulava G.G., Serebrianskaia E.I., Malyants A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/1258

Длительно незаживающие раны не несут непосредственную угрозу для жизни пациентов, но они могут являться воротами для присоединения инфекции и в последующем приводить к развитию септического состояния и как следствие возможному летальному исходу. Несмотря на то, что проблема не нова, адекватного эффективного и малоинвазивного лечения на данный момент времени не существует. Задачей данного литературного обзора был анализ научной литературы с использованием баз данных PubMed, Google Scholar, eLibrary в период 2020–2025 г. с фокусом на систематические обзоры и метаанализы, для оценки перспективы использования PRP терапии как комбинированного метода в лечении длительно незаживающих ран, в частности пролежневых дефектов. По результатам проведенного анализа литературы было выявлено, что тема считается востребованной по всему миру т.к. актуальные метаанализы публиковались за последние 5 лет, в большей степени в зарубежных источниках. По данным проанализированных источников PRP эффективна и безопасна и может быть использована в качестве потенциального терапевтического средства. Полученные данные безусловно дают данной области клеточной регенеративной медицины перспективу для будущих научных исследований.

Long-term non-healing wounds do not pose an immediate threat to patients’ lives, but they can serve as entry points for infection, potentially leading to septic conditions and, consequently, a possible fatal outcome. Although this problem is not new, there is currently no adequately effective and minimally invasive treatment available. The aim of this literature review was to analyze scientific publications using the PubMed, Google Scholar, and eLIBRARY databases for the period 2020–2025, focusing on systematic reviews and meta-analyses to assess the prospects of using PRP therapy as a combined approach in treating long-term non-healing wounds, particularly pressure ulcer defects. The analysis revealed that the topic is globally relevant, as up-to-date meta-analyses have been published over the past five years, mostly in foreign sources. According to the analyzed literature, PRP is effective and safe and can be considered a potential therapeutic agent. The obtained data undoubtedly provide promising prospects for future research in this area of cellular regenerative medicine.

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The authors declare that there are no conflicts of interest present.