uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2026-33-2-75-88uzspbgmu-1216Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSБиомаркеры остеоартрита суставов кисти: ключ к персонифицированному алгоритму лечебно-диагностической тактикиBiomarkers of hand osteoarthritis: the key to a personalized algorithm of treatment and diagnostic tacticshttps://orcid.org/0000-0002-7389-7846ФилатоваТ. А.FilatovaT. A.

Филатова Татьяна Анатольевна, ассистент кафедры общей врачебной практики (семейной медицины) 

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Filatova Tatiana A., Assistant of the Department of General Medical Practice (Family Medicine) 

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

tatyanafilatova90@mail.ruhttps://orcid.org/0000-0002-6457-5044ШапороваН. Л.ShaporovaN. L.

Шапорова Наталия Леонидовна, доктор медицинских наук, профессор, зав. кафедрой общей врачебной практики (семейной медицины)

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Shaporova Nataliia L., Dr. of Sci. (Med.), Professor, Head of the Department of General Medical Practice (Family Medicine)

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

shapnl@mail.ruhttps://orcid.org/0000-0002-7241-5059ДудинаО. В.DudinaO. V.

Дудина Ольга Владимировна, кандидат медицинских наук, доцент кафедры общей врачебной практики (семейной медицины)

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Dudina Olga V., Cand. of Sci. (Med.), Associate Professor of the Department of General Medical Practice (Family Medicine)

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

o-dudina@mail.ruhttps://orcid.org/0000-0001-7265-7392ГалкинаО. В.GalkinaO. V.

Галкина Ольга Владимировна, кандидат биологических наук, доцент, зав. лабораторией биохимического гомеостаза НИИ Нефрологи

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Galkina Olga V., Cand. of Sci. (Biol.), Associate Professor, Head of the Laboratory of Biochemical Homeostasis, Research Institute of Nephrology

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

ovgalkina@mail.ruhttps://orcid.org/0000-0001-8419-6909МедведеваА. О.MedvedevaA. O.

Медведева Анастасия Олеговна, лаборант лаборатории биохимического гомеостазаНИИ Нефрологии 

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Medvedeva Anastasiia O., Laboratory Assistant of the Laboratory of Biochemical Homeostasis, Research Institute of Nephrology

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

anastasy.95@mail.ruhttps://orcid.org/0000-0002-4282-8717ТишковА. В.TishkovA. V.

Тишков Артем Валерьевич, кандидат физико-математических наук, доцент, зав. кафедрой физики, математики и информатики

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Tishkov Artem V., Cand. of Sci. (Physico-Mathematical), Associate Professor, Head of the Department of Physics, Mathematics and Computer Science

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

artem.tishkov@gmail.comhttps://orcid.org/0009-0003-9795-5160ОмироваН. И.OmirovaN. I.

Омирова Наргиз Идаят кызы, кандидат технических наук, доцент кафедры физики, математики и информатики

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Omirova Nargiz I., Cand. of Sci. (Technical), Associate Professor of the Department of Physics, Mathematics and Computer Science

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

nargizomirova@gmail.comhttps://orcid.org/0009-0009-0622-1481ГригорьеваЕ. А.GrigorevaE. A.

Григорьева Евгения Андреевна, врач-дерматовенеролог амбулаторного отделения клиники дерматовенерологии 

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8 

Grigoreva Evgeniia A., Dermatovenerologist of the Outpatient Department of the Clinic of Dermatovenerology 

6-8, L’va Tolstogo str., Saint Petersburg, 197022 

grigorieva_job@mail.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov UniversityRussian Federation2026091020263327588Copyright © Филатова Т.А., Шапорова Н.Л., Дудина О.В., Галкина О.В., Медведева А.О., Тишков А.В., Омирова Н.И., Григорьева Е.А., 20262026Филатова Т.А., Шапорова Н.Л., Дудина О.В., Галкина О.В., Медведева А.О., Тишков А.В., Омирова Н.И., Григорьева Е.А.Filatova T.A., Shaporova N.L., Dudina O.V., Galkina O.V., Medvedeva A.O., Tishkov A.V., Omirova N.I., Grigoreva E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/1216Введение

Введение. Остеоартрит суставов кисти (ОАСК) относится к малоизученным формам заболевания, в том числе не определены биомаркеры, обладающие диагностической и прогностической ценностью.

Цель – изучить роль ряда биомаркеров у пациентов с ОАСК.

Методы и материалы

Методы и материалы. В исследование были включены 52 женщины, страдающие ОАСК. У всех определяли уровень боли, утренней скованности и функциональных нарушений. Лабораторное обследование включало определение скорости оседания эритроцитов (СОЭ), С-реактивного белка (СРБ), интерлейкин-1 бета (ИЛ-1β), остеокальцина, олигомерного матриксного белка (СОМР) и С-концевых телопептидов коллагена II типа в моче (uCTX-II). Всем женщинам были выполнены рентгенография суставов кисти и денситометрия.

Результаты

Результаты. Было выявлено повышение уровня COMP в подгруппе возраста «50–65 лет», в то время как значения СОЭ, СРБ, ИЛ-1β, uCTX-II, COMP и остеокальцина в исследуемой группе находились в референсном диапазоне. Использование ИЛ-1β в диагностике ОАСК ограничено его крайне низкой концентрацией в крови, однако маркер может являться предиктором более тяжелого течения патологии у пациенток с ожирением. Значимых корреляционных связей между исследуемыми биомаркерами и функциональными параметрами не выявлено. В отличие от индекса массы тела (ИМТ) и минеральной плотности кости (МПК), возраст и менопауза не оказали существенного влияния на анализируемые параметры.

Выводы

Выводы. Определение uCTX-II и COMP, возможно, целесообразно в диагностике не только ОАСК в целом, но и остеопоротического фенотипа ОАСК в частности.

Introduction

Introduction. Hand osteoarthritis (HOA) is a poorly studied form of the disease, and biomarkers with diagnostic and prognostic value have not been identified yet.

The objective was to study the role of some biomarkers in patients with НОА.

Materials and methods

Materials and methods. 52 women with НОА were included into the study. The degree of pain, morning stiffness and functional impairment in hand joints was determined in all patients. The laboratory examination included determination of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-1 beta (IL-1β), osteocalcin, cartilage oligomeric matrix protein (COMP) and C-terminal telopeptides of type II collagen in urine (uCTX-II). All women underwent hand joint radiography and densitometry.

Results

Results. COMP increase was detected in the «50-65 years» age subgroup, while the values of ESR, CRP, IL-1β, uCTX-II, COMP and osteocalcin in the study group were within the reference range. The use of IL-1β in the diagnosis of НOA is limited by its extremely low concentration in the blood, but the biomarker may be a predictor of a more severe course of the disease in obese patients. No significant correlations were found between the studied biomarkers and functional parameters. In contrast to the body mass index (BMI) and bone mineral density (BMD), age and menopause did not have significant effect on the studied parameters.

Conclusions

Conclusions. The determination of uCTX-II and COMP is potentially useful in the diagnosis of not only НOA in general, but also the osteoporotic phenotype of НOA in particular.

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The authors declare that there are no conflicts of interest present.