References

uzspbgmu

Учёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. Павлова

The Scientific Notes of the Pavlov University

1607-41812541-8807

Academician I.P. Pavlov First St. Petersburg State Medical University

10.24884/1607-4181-2025-32-3-42-52

uzspbgmu-1196

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

Ингибиторы фосфоинозитол-3-киназ (PI3K) на основе производных 1,3,5-триазина для таргетной противоопухолевой терапии

Phosphoinositol-3-kinase (PI3K) inhibitors based on 1,3,5-triazine derivatives for targeted antitumor therapy

https://orcid.org/0009-0009-8950-884X

Чернов

И. С.

Chernov

I. S.

Чернов Иван Сергеевич, аспирант кафедры общей и биоорганической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Chernov Ivan S., Postgraduate Student of the Department of General and Bioorganic Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0002-6513-6983

Попова

Е. С.

Popova

E. A.

Попова Елена Александровна, доктор химических наук, профессор кафедры общей и биоорганической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Popova Еlena А., Dr. of Sci. (Chem.), Professor of the Department of General and Bioorganic Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0002-1920-9360

Протас

А. В.

Protas

A. V.

Протас Александра Владимировна, кандидат химических наук, доцент кафедры общей и биоорганической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Protas Aleksandra V., Cand. of Sci. (Chem.), Associate Professor of the Department of General and Bioorganic Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0003-3330-6324

Молчанов

О. Е.

Molchanov

O. E.

Молчанов Олег Евгеньевич, доктор медицинских наук, руководитель отдела фундаментальных исследований

197758, Санкт-Петербург, поселок Песочный, ул. Ленинградская, д. 70

Molchanov Oleg E., Dr. of Sci. (Med.), Head of the Department of Fundamental Researches

70, Leningradskaya str., Saint Petersburg, Pesochny settlement, 197758

https://orcid.org/0000-0002-3717-0471

Шаройко

В. В.

Sharoyko

V. V.

Шаройко Владимир Владимирович, доктор биологических наук, профессор кафедры общей и биоорганической химии; ведущий научный сотрудник кафедры химии твердого тела Института химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

199034, Санкт-Петербург, Университетская набережная, д. 7–9

Sharoyko Vladimir V., Dr. of Sci. (Biol.), Professor of the Department of General and Bioorganic Chemistry; Leading Research Fellow of the Department of Solid State Chemistry, Institute of Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

7-9 Universitetskaya Embankment, Saint Petersburg, 199034

sharoyko@gmail.com

https://orcid.org/0000-0003-2239-2044

Семенов

К. Н.

Semenov

K. N.

Семенов Константин Николаевич, доктор химических наук, профессор кафедры общей и биоорганической химии; профессор кафедры химии твердого тела Института химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

199034, Санкт-Петербург, Университетская набережная, д. 7–9

Semenov Konstantin N., Dr. of Sci. (Chem.), Professor of the Department of General and Bioorganic Chemistry; Professor of the Department of Solid State Chemistry, Institute of Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

7-9 Universitetskaya Embankment, Saint Petersburg, 199034

Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. ПавловаРоссияPavlov UniversityRussian Federation

Российский научный центр радиологии и хирургических технологий имени академика А. М. ГрановаРоссияA. M. Granov Russian Research Centre for Radiology and Surgical TechnologiesRussian Federation

Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Санкт-Петербургский государственный университетРоссияPavlov University; St. Petersburg State UniversityRussian Federation

2025

16122025

3234252

2025

Чернов И.С., Попова Е.С., Протас А.В., Молчанов О.Е., Шаройко В.В., Семенов К.Н.

Chernov I.S., Popova E.A., Protas A.V., Molchanov O.E., Sharoyko V.V., Semenov K.N.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.sci-notes.ru/jour/article/view/1196

Фосфоинозитол-3-киназы (PI3K) могут рассматриваться в качестве мишеней для таргетной терапии злокачественных новообразований. 1,3,5-триазиновый цикл является перспективным скаффолдом при разработке противоопухолевых агентов, действующих на различные биологические мишени опухолевых клеток. В настоящем обзоре рассматриваются производные 1,3,5-триазина (s-триазина) с высокой ингибирующей активностью в отношении PI3K. В том числе обобщены данные по основным структурным фрагментам, играющим ключевую роль в образовании взаимодействий биологически активных соединений с сайтами PI3K. Показана перспективность направления, связанного с разработкой бифункциональных агентов, одновременно воздействующих на две биологические мишени одного или разных сигнальных путей.

Phosphoinositol-3-kinases (PI3K) may be considered as targets for targeted therapy of tumors. The 1,3,5-triazine core is considered the promising scaffold in antitumor drug development, that affect to various targets in tumor cells. This review examines 1,3,5-triazine derivatives (s-triazine) with strong inhibitory activity against PI3K kinases. Moreover, the key structural fragments that play a crucial role in binding to the active sites of PI3K are summarized. The prospects of developing bifunctional agents, which simultaneously affect two or more targets within the same or different signaling pathways, are also discussed.

135-триазинфосфоинозитол-3-киназы (PI3K)ингибирующая активностьтаргетные противоопухолевые препараты

135-triazinephosphoinositide-3-kinases (PI3K)inhibitory activitytargeted antitumor drugs

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The authors declare that there are no conflicts of interest present.