uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2015-22-1-60-64uzspbgmu-115Research ArticleОРИГИНАЛЬНЫЕ РАБОТЫORIGINAL PAPERSИЗМЕНЕНИЕ УРОВНЯ АДИПОНЕКТИНА И МЕТАБОЛИЧЕСКИХ ПОКАЗАТЕЛЕЙ ПРИ МОДИФИКАЦИИ ОБРАЗА ЖИЗНИ У БОЛЬНЫХ АБДОМИНАЛЬНЫМ ОЖИРЕНИЕМChange of the level of adiponectin and metabolic indices in modification of life style of the patients suffering from abdominal obesityБерезинаА. В.BeresinaA. V.noemail@neicon.ruБеляеваО. Д.BelyaevaO. D.noemail@neicon.ruБерковичО. А.BerkovichO. A.noemail@neicon.ruКароноваТ. Л.KaronovaT. L.noemail@neicon.ruБаженоваЕ. А.BazhenovaE A.noemail@neicon.ruКарельскаяН. А.KarelskayaN. A.noemail@neicon.ruБарановаЕ. И.BaranovaE. I.noemail@neicon.ruИнститут сердца и сосудов Федеральный центр сердца, крови и эндокринологии имени В. А. АлмазоваRussian Federation2015300320152216064Copyright © Березина А.В., Беляева О.Д., Беркович О.А., Каронова Т.Л., Баженова Е.А., Карельская Н.А., Баранова Е.И., 20152015Березина А.В., Беляева О.Д., Беркович О.А., Каронова Т.Л., Баженова Е.А., Карельская Н.А., Баранова Е.И.Beresina A.V., Belyaeva O.D., Berkovich O.A., Karonova T.L., Bazhenova E.A., Karelskaya N.A., Baranova E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/115

В работе были изучены особенности питания, физических нагрузок, антропометрических и метаболических показателей и выявлена степень их изменений, необходимых для увеличения уровня адипонектина при немедикаментозном лечении больных абдоминальным ожирением. Было проведено 3-летнее проспективное исследование по модификации образа жизни у 153 больных АО в возрасте 30 - 55 лет. Пациенты были рандомизированы в 2 группы лечения: диетой - 74 человека и сочетания диеты и физической нагрузки - 79 человек. Всем больным были даны индивидуальные рекомендации по изменению образа жизни. В ходе исследования оценивались динамика антропометрических, метаболических параметров, уровня адипонектина и изменение характера питания и физической активности. Была установлена взаимосвязь между сниженным уровнем АН и метаболическими изменениями, характером питания и физической активностью у больных АО. Установлены пороговые значения снижения антропометрических показателей, калорийности и жирности питания, а также повышения уровня физической работоспособности, при достижении которых уровень адипонектина повышается.

The paper studied nutritional habits, physical loads, anthropometric and metabolic perfromances, and revealed the changes required to increase the level of adiponectine under drug-free modalities of treatment of patients suffering from abdominal obesity. A 3-year randomized lifestyle intervention trial was performed in 153 patients with AO, age 30-53 yrs, 74 patients (group 1) performed individual hypocaloric diet balanced in fat intake, 79 patients (group 2) performed diet and individual aerobic exercise All patients received individual recommendations on changing their life style. Dynamics of anthropometric, metabolic parameters, physical capacity and adiponectin level were measured. Relation between low level of adiponectin and some metabolic disorders, and sedentary life were revealed. The rate of improving anthropometric parameters, physical capacity, and nutritionassociated with increasing adiponectin was established.

адипонектинабдоминальное ожирениехарактер питанияфизическая активностьadiponectinabdominal obesitynutritionphysical activityReferencesМеждународный опросник по оценке физической активности (International Physical Activity Questionnaire - IPAQ), 2005. URL: http://www.ipaq.ki.seМеждународный опросник по оценке физической активности (International Physical Activity Questionnaire - IPAQ), 2005. URL: http://www.ipaq.ki.seAnderlova K., Kremen J., Dolezalova R. et. al. The influence of very-low-caloric-diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women // Physiol. Res. - 2006. - № 55. - P. 27.Anderlova K., Kremen J., Dolezalova R. et. al. The influence of very-low-caloric-diet on serum leptin, soluble leptin receptor, adiponectin and resistin levels in obese women // Physiol. Res. - 2006. - № 55. - P. 27.Armstrong L., Balady G., Berry M. et al. ACSM's guidelines for exercise testing and prescription // LWW. - 7th ed. - 2005.Armstrong L., Balady G., Berry M. et al. ACSM's guidelines for exercise testing and prescription // LWW. - 7th ed. - 2005.Blucher M., Williams C., Kloting N. et al. Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical Training // Diabetes Care. - 2007. - Vol. 30. - № 12. - P. 3110 - 3115.Blucher M., Williams C., Kloting N. et al. Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical Training // Diabetes Care. - 2007. - Vol. 30. - № 12. - P. 3110 - 3115.Bonadonna R. C., Groop L., Kraemer N. et al. Obesity and insulin resistance in humans: a dose-response study // Metabolism. - 1990. - Vol. 39. - № 5. - P. 452 - 459.Bonadonna R. C., Groop L., Kraemer N. et al. Obesity and insulin resistance in humans: a dose-response study // Metabolism. - 1990. - Vol. 39. - № 5. - P. 452 - 459.Cassidy A., Skidmore P., Romm E. et al. Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in femela twins // J. Nutr. - 2009. - Vol. 139. - № 2. - P. 353 - 358.Cassidy A., Skidmore P., Romm E. et al. Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in femela twins // J. Nutr. - 2009. - Vol. 139. - № 2. - P. 353 - 358.Hotta R., Funahashi T., Atita Y. et. al. Plasma concentration of a novel adipose-specificprotein, adiponectin, in type 2 diabetic patients // Arterioscler. Thromb. Vasc. Biol. - 2000. - № 20. - P. 1595-1599.Hotta R., Funahashi T., Atita Y. et. al. Plasma concentration of a novel adipose-specificprotein, adiponectin, in type 2 diabetic patients // Arterioscler. Thromb. Vasc. Biol. - 2000. - № 20. - P. 1595-1599.Kraemer R., Aboudehen K., Carruth A. et. al. Adiponectin responses to continuos and progressively intense intermittent exercise // Med. Sci. Sports Exerc. - 2003. - Vol. 35. - № 8. - P. 1320-1325.Kraemer R., Aboudehen K., Carruth A. et. al. Adiponectin responses to continuos and progressively intense intermittent exercise // Med. Sci. Sports Exerc. - 2003. - Vol. 35. - № 8. - P. 1320-1325.Matsubara M., Maruoka S., Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal weight and obese women // Eur. J. Endocrinol. - 2002. - № 147. - P. 173- 180.Matsubara M., Maruoka S., Katayose S. Inverse relationship between plasma adiponectin and leptin concentrations in normal weight and obese women // Eur. J. Endocrinol. - 2002. - № 147. - P. 173- 180.Mitterberger M., Mattesich M., Klaver E. et al. Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction // J. Gerontol. A Biol. Sci. Med. Sci. - 2010. - Vol. 65. - № 9. - P. 915 - 923.Mitterberger M., Mattesich M., Klaver E. et al. Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction // J. Gerontol. A Biol. Sci. Med. Sci. - 2010. - Vol. 65. - № 9. - P. 915 - 923.Monzillo L., Hamdy O., Horton E. et. al. Effect of life-style modification on adipokine levels in obese subjects with insulin resistance // Obes. Res. - 2003. - № 11. - P. 1048-1054.Monzillo L., Hamdy O., Horton E. et. al. Effect of life-style modification on adipokine levels in obese subjects with insulin resistance // Obes. Res. - 2003. - № 11. - P. 1048-1054.Oberhach A., Tonjes A., Kloting N. et. al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abdominal glucose tolerance // Eur. J. Endocrinol. - 2006. - Vol. 154. - № 4. - P. 577 - 585.Oberhach A., Tonjes A., Kloting N. et. al. Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abdominal glucose tolerance // Eur. J. Endocrinol. - 2006. - Vol. 154. - № 4. - P. 577 - 585.Pischon T., Girman C., Rifai N. et al. Association between dietary factors and plasma adiponectin concentrations in men // Am. J. Clin. Nutr. - 2005. - Vol. 81. - № 4. - P. 780 - 786.Pischon T., Girman C., Rifai N. et al. Association between dietary factors and plasma adiponectin concentrations in men // Am. J. Clin. Nutr. - 2005. - Vol. 81. - № 4. - P. 780 - 786.Qi L., Rimm E., Liu S. et al. Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men // Diabetes Care. - 2005. - Vol. 28. - № 5. - P. 1022- 1028.Qi L., Rimm E., Liu S. et al. Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men // Diabetes Care. - 2005. - Vol. 28. - № 5. - P. 1022- 1028.Ring-Dimitriou S., Paulweber B., von Duvillard S. et. al. The effect of physical activity and physical fitness on plasma adiponectin in adults with perdiposition to metabolic syndrome // Eur. J. Appl. Physiol. - 2006. - № 98 (S). - P. 472 - 481.Ring-Dimitriou S., Paulweber B., von Duvillard S. et. al. The effect of physical activity and physical fitness on plasma adiponectin in adults with perdiposition to metabolic syndrome // Eur. J. Appl. Physiol. - 2006. - № 98 (S). - P. 472 - 481.Silva F., Almeida J., Feoli A. Effect of diet on adiponectin levels in blood // Nutrition Review. - 2011. - Vol. 69. - № 10. - P. 599 - 612.Silva F., Almeida J., Feoli A. Effect of diet on adiponectin levels in blood // Nutrition Review. - 2011. - Vol. 69. - № 10. - P. 599 - 612.Tsukinoki R., Morimoto K., Nakayama K. Association between lifestyle factors and plasma adiponectin levels in Japanese men // Lipids in health and disease. - 2005. - № 4. - Р. 27.Tsukinoki R., Morimoto K., Nakayama K. Association between lifestyle factors and plasma adiponectin levels in Japanese men // Lipids in health and disease. - 2005. - № 4. - Р. 27.

The authors declare that there are no conflicts of interest present.