uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2024-31-2-19-27uzspbgmu-1065Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСтатус глутатиона эритроцитов в клинической медицине: реальность и возможностиThe status of erythrocyte glutathione in clinical medicine: reality and possibilitieshttps://orcid.org/0000-0001-5962-7105АлександроваЛ. А.AlexandrovaL. A.

Александрова Людмила Александровна - кандидат биологических наук, старший научный сотрудник, отдел биохимии НОИ биомедицины.

197022, СанктПетербург, ул. Льва Толстого, д. 6-8

Aleksandrova Liudmila A. - Cand. of Sci. (Biol.), Senior Research Fellow, Department of Biochemistry of the Scientific and Educational Institute of Biomedicine.

6-8, L’va Tolstogo str., Saint Petersburg, 197022

LAA2004@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2024031120243121927Copyright © Александрова Л.А., 20242024Александрова Л.А.Alexandrova L.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/1065

В обзоре рассматривается состояние процессов свободно-радикального окисления в клинической медицине в настоящее время. На основании многолетних исследований и анализа литературы мы считаем наиболее перспективной оценку активности глутатионредуктазы и уровня глутатиона, восстановленного в эритроцитах, как характеристику тиолдисульфидной редокс-системы глутатиона не только для индикации оксидантного стресса, но и возможного прогностического маркера «свободно-радикальных заболеваний».

The review examines the current state of free radical oxidation processes in clinical medicine. Based on many years of our research and analysis of the literature, we consider the most promising assessment of the activity of glutathione reductase and the level of glutathione reduced in erythrocytes, as a characteristic of the thiol-disulfide redox system of glutathione, not only to indicate oxidative stress, but also a possible prognostic marker of “free radical diseases”.

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The authors declare that there are no conflicts of interest present.