uzspbgmuУчёные записки Первого Санкт-Петербургского государственного медицинского университета имени академика И. П. ПавловаThe Scientific Notes of the Pavlov University1607-41812541-8807Academician I.P. Pavlov First St. Petersburg State Medical University10.24884/1607-4181-2023-30-3-36-47uzspbgmu-1049Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESФосфолипаза А2 яда гадюковых. Биохимические мишени для действия белка в кровяном русле человека. Обзор литературы. Часть 2Viperidae snake venom phospholipase A2. Biochemical targets in the human blood circulatory system. Review. Part 2https://orcid.org/0000-0002-2647-6336ВасинаЛ. В.VasinaL. V.

Васина Любовь Васильевна, доктор медицинских наук, зав. кафедрой биологической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Vasina Lyubov V., Dr. of Sci. (Med.), Head of the Department of Biological Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0002-6688-5257ГалебскаяЛ. В.GalebskayaL. V.

Галебская Людвига Вячеславовна, доктор медицинских наук, профессор кафедры биологической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Galebskaya Lyudviga V., Dr. of Sci. (Med.), Professor of the Department of Biological Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0001-6527-5580ГалкинМ. А.GalkinМ. А.

Галкин Михаил Александрович, кандидат  биологических наук, доцент кафедры биологической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Galkin Mikhail A., Cand. of Sci. (Biol.), AssociateProfessor of the Department of Biological Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0002-0026-0166СоловьеваМ. А.SolovyevaМ. А.

Соловьева Марина Алексеевна, ассистент кафедры биологической химии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Solovyeva Marina A., Assistant of the Department of Biological Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

https://orcid.org/0000-0002-3251-0481ТарасоваЮ. В.TarasovaYu. V.

Тарасова Юлия Викторовна, кандидат биологических наук, доцент кафедры биологическойхимии

197022, Санкт-Петербург, ул. Льва Толстого, д. 6-8

Tarasova Yuliya V., Cand. of Sci. (Biol.), Associate Professor of the Department of Biological Chemistry

6-8, L’va Tolstogo str., Saint Petersburg, 197022

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov UniversityRussian Federation2023020420243033647Copyright © Васина Л.В., Галебская Л.В., Галкин М.А., Соловьева М.А., Тарасова Ю.В., 20242024Васина Л.В., Галебская Л.В., Галкин М.А., Соловьева М.А., Тарасова Ю.В.Vasina L.V., Galebskaya L.V., Galkin М.А., Solovyeva М.А., Tarasova Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sci-notes.ru/jour/article/view/1049

В обзоре рассмотрены особенности строения и свойства наиболее изученных фосфолипаз яда змей семейства гадюковых. Также детально анализируются разнообразные эффекты этих ферментов на форменные элементы крови (эритроциты, лейкоциты и тромбоциты), на процессы свертывания крови и агрегацию тромбоцитов. Описываются возможные области и пути применения этих ферментов в фундаментальной и практической медицине.

In this review (Part 2), we describe the structural features and properties of the most studied Viperidae snake venom phospholipases A2 . Various effects of these enzymes on blood cells (erythrocytes, leukocytes and platelets), on blood coagulation and platelet aggregation are also analyzed in details. Possible areas and ways of application of these enzymes in fundamental and practical medicine are discussed.

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The authors declare that there are no conflicts of interest present.